Cusini, A; Günthard, H F; Stussi, G; Schwarz, U; Fehr, T; Grueter, E; Meerbach, A; Bossart, W; Schaer, D J; Rudiger, A (2010). Hemophagocytic syndrome caused by primary herpes simplex virus 1 infection: report of a first case. Infection, 38(5):423-426.
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INTRODUCTION: Hemophagocytic syndrome represents a severe hyperinflammatory condition by activated macrophages. Leading viral triggering agents are Epstein-Barr virus (EBV), cytomegalovirus (CMV), and adenovirus. MATERIALS AND METHODS: We present a patient with Wegener's granulomatosis on azathioprine and prednisone medication, who developed a life-threatening hemophagocytic syndrome. Positive plasma polymerase chain reaction (PCR) with negative serology revealed a primary, disseminated infection with herpes simplex virus-1 as the triggering pathogen. After treatment with acyclovir, high-dose steroids, immunoglobulins, and etoposide, the patient recovered. CONCLUSION: Early diagnosis of potentially underlying infections of hemophagocytic syndrome influences the therapeutic approach. It is important to consider a variety of infectious agents, particularly in immunosuppressed individuals. The reported case emphasizes the importance of screening for herpes simplex virus 1.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Clinic and Policlinic for Internal Medicine|
04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurology
04 Faculty of Medicine > University Hospital Zurich > Clinic for Infectious Diseases
|DDC:||610 Medicine & health|
|Deposited On:||17 Aug 2010 15:01|
|Last Modified:||27 Nov 2013 23:52|
|Citations:||Web of Science®. Times Cited: 2|
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