Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive 

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-35524

Wimmershoff, J; Polkinghorne, A; Grest, P; Schade, B; Marchal, T; Keller, S M; Guscetti, F (2010). Immunohistochemical detection of survivin in canine lymphoma. Journal of Comparative Pathology, 142(4):311-322.

[img] PDF - Registered users only
4MB
[img]Accepted Version
PDF
1MB

Abstract

Survivin is a member of the family of proteins known as 'inhibitors of apoptosis proteins'. Survivin has a role in cellular decisions concerning division and survival and is frequently expressed in neoplastic cells. The aim of the present study was to investigate immunohistochemically the expression of survivin in normal canine tissues and in canine lymphoma. A representative range of fetal and adult normal tissues as well as biopsy samples from dogs with lymphoma were assembled in tissue arrays. The lymphomas were classified according to the revised Kiel and to the Revised European American Lymphoma-World Health Organization (REAL-WHO) schemes. Polyclonal and monoclonal antisera cross-reactive with canine survivin identified cytoplasmic expression of the molecule in a broad range of normal canine cells. The same reagents demonstrated cytoplasmic labelling of more than 5% of cells in all 83 lymphoma samples tested with polyclonal antiserum and in 67 of 82 (82%) of samples tested with monoclonal antiserum. Survivin was expressed by a wide range of canine lymphoma subtypes, but the expression of this molecule in normal canine tissues must be considered if novel therapies targeting survivin are applied to the management of canine lymphoma.

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Institute of Veterinary Pathology
DDC:570 Life sciences; biology
Language:English
Date:2010
Deposited On:28 Sep 2010 15:13
Last Modified:27 Nov 2013 20:00
Publisher:Elsevier
ISSN:0021-9975
Publisher DOI:10.1016/j.jcpa.2009.12.004
Related URLs:https://www.zora.uzh.ch/35522/
PubMed ID:20116802
Citations:Web of Science®. Times Cited: 3
Google Scholar™
Scopus®. Citation Count: 3

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page