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Haerle, S K; Strobel, K; Ahmad, N; Soltermann, A; Schmid, D T; Stoeckli, S J (2011). Contrast-enhanced (18)F-FDG-PET/CT for the assessment of necrotic lymph node metastases. Head and Neck, 33(3):324-329.

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Abstract

BACKGROUND.: Cystic lymph node metastasis (CLNM) is commonly found in human papillomavirus (HPV)-associated tonsillar squamous cell carcinoma (SCC). The aim of this study was to compare the accuracy in detecting cystic lymph node metastasis from tonsillar SCC between contrast-enhanced CT, (18)F- fluorodeoxyglucose-positron emission tomography (FDG-PET), non-enhanced (18)F-FDG-PET/CT, and contrast-enhanced (18)F-FDG-PET/CT. METHODS.: Thirty-four patients with a tonsillar SCC undergoing a pretreatment contrast-enhanced (18)F-FDG-PET/CT followed by a neck dissection as a standard of reference were included. The contrast-enhanced CT part, the (18)F-FDG-PET part, the non-enhanced (18)F-FDG-PET/CT part, and the contrast-enhanced (18)F-FDG-PET/CT were assessed separately for correct N classification and the differentiation of N0 versus N+. RESULTS.: Contrast-enhanced (18)F-FDG-PET/CT, non-enhanced (18)F-FDG-PET/CT, and contrast-enhanced CT are equally accurate for correct neck staging. Regarding pN0 versus pN+, contrast-enhanced CT and contrast-enhanced (18)F-FDG-PET/CT are superior to non-enhanced (18)F-FDG-PET/CT (p = .017). CONCLUSION.: Contrast-enhanced CT and contrast-enhanced (18)F-FDG-PET/CT perform equally and better than non-enhanced (18)F-FDG-PET/CT in detecting CLNM in tonsillar SCC. Therefore, in patients scheduled for (18)F-FDG-PET/CT, we strongly suggest performing a contrast-enhanced (18)F-FDG-PET/CT, which is not routine in most centers. (c) 2010 Wiley Periodicals, Inc. Head Neck, 2010.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Otorhinolaryngology
04 Faculty of Medicine > University Hospital Zurich > Institute of Surgical Pathology
04 Faculty of Medicine > University Hospital Zurich > Clinic for Nuclear Medicine
DDC:610 Medicine & health
Language:English
Date:March 2011
Deposited On:25 Aug 2010 13:32
Last Modified:27 Nov 2013 21:06
Publisher:Wiley-Blackwell
ISSN:1043-3074
Publisher DOI:10.1002/hed.21447
PubMed ID:20652890
Citations:Web of Science®. Times Cited: 14
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Scopus®. Citation Count: 17

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