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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-35607

Martin-Soelch, C (2010). Modelle der Substanzabhängigkeit. Neurobiologische und neuropsychologische Modelle der Substanzabhängigkeit. Zeitschrift für Neuropsychologie, 21(3):153-166.

Accepted Version


Neurobiological models of substance dependence hypothesize that addiction results from interplay between positive and negative reinforcement. Positive reinforcing effects of drugs are mediated through dopamine transmission in the striatum, while negative reinforcement involves the central stress systems. Substance dependence leads to persistent changes in the brain motivational systems. Neuropsychological research showed impairment in decision-making that could be related to a dysfunction in the ventromedial prefrontal cortex. A further critical region is the insula that could be involved in the impaired insight in addictive behaviour and in the mediation of the conscious urge to take the drug. Neurobiological and neuropsychological perspectives are integrated here in a model combining impulsive subcortical and dopamine-related processes with dysfunction of cortical inhibition and cognitive deficits.

Other titles:Neurobiological and Neuropsychological Perspectives on Substance Dependence
Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Psychiatry and Psychotherapy
DDC:610 Medicine & health
Uncontrolled Keywords:Substanzabhängigkeit; Sucht; Belohnung; Dopamin; Verstärker; Neurobiologie, Neuropsychologie, dependence, addiction, reward, dopamine, reinforcement, neurobiology, neuropsychology
Date:September 2010
Deposited On:27 Oct 2010 12:46
Last Modified:27 Nov 2013 17:03
Publisher:Hans Huber
Additional Information:Diese Artikelfassung entspricht nicht vollständig dem in der Zeitschrift veröffentlichten Artikel. Dies ist nicht die Originalversion des Artikels und kann daher nicht zur Zitierung herangezogen werden.
Publisher DOI:10.1024/1016-264X/a000015
Citations:Web of Science®. Times Cited: 4
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Scopus®. Citation Count: 5

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