Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive 

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-35748

Port, F; Basler, K (2010). Wnt trafficking: new insights into Wnt naturation, secretion and spreading. Traffic, 11(10):1265-1271.

[img]PDF - Registered users only
636Kb

Abstract

Proteins of the Wnt family are secreted signaling molecules that regulate multiple processes in animal development and control tissue homeostasis in the adult. Wnts spread over considerable distances to regulate gene expression in cells located at distant sites. Paradoxically, Wnts are poorly mobile because of their posttranslational modification with lipids. Recent evidence suggests that several pathways exist that are capable of transforming hydrophobic, insoluble Wnts into long-range signaling molecules. Furthermore, the discovery of Wntless as a protein specifically required for the secretion of Wnt suggests that Wnt trafficking through the secretory pathway is already under special scrutiny. Here, we review recent data on the molecular machinery that controls Wnt secretion and discuss how Wnts can be mobilized for long-range signaling.

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
DDC:570 Life sciences; biology
Language:English
Date:2010
Deposited On:03 Nov 2010 10:55
Last Modified:02 Dec 2013 18:16
Publisher:Wiley-Blackwell
ISSN:1398-9219
Publisher DOI:10.1111/j.1600-0854.2010.01076.x
PubMed ID:20477987
Citations:Web of Science®. Times Cited: 43
Google Scholar™

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page