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Parallel visual cycles in the zebrafish retina


Fleisch, V C; Neuhauss, S C F (2010). Parallel visual cycles in the zebrafish retina. Progress in Retinal and Eye Research, 29(6):476-486.

Abstract

Vertebrate vision necessitates continuous recycling of the chromophore 11-cis retinal (RAL). The classical (or canonical) visual cycle employs a number of enzymes located in the photoreceptor outer segment and RPE (retinal pigment epithelium) of the retina to regenerate 11-cis RAL from all-trans RAL. Cone-dominant species are believed to utilize a second, intra-retinal, pathway for 11-cis RAL generation, involving retinal Müller glia cells. This review summarizes the efforts made in zebrafish to gain a better understanding of the role of these two visual cycles for rod and cone photoreceptor chromophore recycling.

Vertebrate vision necessitates continuous recycling of the chromophore 11-cis retinal (RAL). The classical (or canonical) visual cycle employs a number of enzymes located in the photoreceptor outer segment and RPE (retinal pigment epithelium) of the retina to regenerate 11-cis RAL from all-trans RAL. Cone-dominant species are believed to utilize a second, intra-retinal, pathway for 11-cis RAL generation, involving retinal Müller glia cells. This review summarizes the efforts made in zebrafish to gain a better understanding of the role of these two visual cycles for rod and cone photoreceptor chromophore recycling.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
Dewey Decimal Classification:570 Life sciences; biology
Uncontrolled Keywords:Visual Cycle, RetinoidCycle, Zebrafish, Cone Photoreceptor, Müller GliaCell, CRALBP
Language:English
Date:19 November 2010
Deposited On:09 Nov 2010 12:23
Last Modified:05 Apr 2016 14:15
Publisher:Elsevier
ISSN:1350-9462
Publisher DOI:10.1016/j.preteyeres.2010.05.001
PubMed ID:20488254
Permanent URL: http://doi.org/10.5167/uzh-35821

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