Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-35889
Haerle, S K; Fischer, D R; Schmid, D T; Ahmad, N; Huber, G F; Buck, A (2011). (18)F-FET PET/CT in advanced head and neck squamous cell carcinoma: an intra-individual comparison with (18)F-FDG PET/CT. Molecular Imaging and Biology, 13(5):1036-1042.
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PURPOSE: To assess the diagnostic value of O-2-fluoro-18(F)-ethyl-L: -tyrosine ((18)F-FET) positron emission tomography/computed tomography (PET/CT) for patients with advanced head and neck squamous cell carcinoma compared with 18F-fluoro-2-deoxy-D: -glucose ((18)F-FDG) PET/CT at initial staging and following radiochemotherapy. PROCEDURES: Thirteen patients were prospectively enrolled; each of them underwent an (18)F-FDG PET/CT and (18)F-FET PET/CT before treatment. Ten of those were scanned 10 weeks after treatment. RESULTS: Sensitivity, specificity, and accuracy for (18)F-FDG PET/CT (primary and lymph node metastases) at initial staging were 89%, 50%, and 81%. For (18)F-FET PET/CT the numbers were 70%, 90%, and 74%. Sensitivity, specificity, and accuracy for (18)F-FDG PET/CT at follow-up were 71%, 65%, and 67%. For (18)F-FET PET/CT the numbers were 29%, 100%, and 83%. Additionally, (18)F-FDG PET/CT detected a higher number of second malignancies or distant metastases. CONCLUSIONS: (18)F-FET is no substitute for (18)F-FDG. Although it is more specific, too many malignant lesions are missed due to its lower sensitivity.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Clinic for Nuclear Medicine|
04 Faculty of Medicine > University Hospital Zurich > Clinic for Otorhinolaryngology
|DDC:||610 Medicine & health|
|Deposited On:||24 Sep 2010 13:21|
|Last Modified:||14 Dec 2012 12:25|
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