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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-36088

Buechel, R R; Husmann, L; Pazhenkottil, A P; Nkoulou, R; Herzog, B A; Burger, I A; Ghadri, J R; Wolfrum, M; Kaufmann, P A (2010). Myocardial perfusion imaging with real-time respiratory triggering: impact of inspiration breath-hold on left ventricular functional parameters. Journal of Nuclear Cardiology, 17(5):848-52.

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BACKGROUND: The latest gamma-camera generation with cadmium-zinc-telluride (CZT) detectors allows myocardial perfusion imaging (MPI) with respiratory triggering at breath-hold. We assessed its impact on functional left ventricular (LV) parameters. METHODS: Twenty-eight consecutive patients underwent a one-day (99m)Tc-tetrofosmin pharmacologic stress/rest imaging protocol on a novel CZT camera. Electrocardiogram-gated high-dose (rest) MPI was performed without and with real-time respiratory triggering by intermittent scanning confined to breath-hold at deep inspiration. We studied the effect of respiratory triggering at deep inspiration levels on LV wall motion, wall thickening, LV volumes and ejection fraction (LVEF) compared to regular MPI without respiratory triggering. RESULTS: Compared to regular MPI without respiratory triggering, systolic and diastolic LV volumes and stroke volumes decreased significantly (P < 0.05) when respiratory triggering was applied. By contrast, there was no significant change in LVEF, with a high correlation (r = .939, P < 0.001) between the two measurements. Furthermore, respiratory triggering introduced a significant change (P < 0.05) in regional LV wall motion. CONCLUSIONS: Respiratory-triggered MPI with breath-hold at deep inspiration levels introduces significant changes to the measured LV volumes, stroke volumes and regional wall motion but does not significantly affect global LVEF when compared to regular MPI with normal breathing.


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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Center for Integrative Human Physiology
04 Faculty of Medicine > University Hospital Zurich > Clinic for Nuclear Medicine
04 Faculty of Medicine > University Hospital Zurich > Clinic for Cardiology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Date:October 2010
Deposited On:12 Nov 2010 15:27
Last Modified:05 Apr 2016 14:15
Publisher DOI:10.1007/s12350-010-9232-4
PubMed ID:20414755

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