Quick Search:

uzh logo
Browse by:

Zurich Open Repository and Archive

Maintenance: Tuesday, July the 26th 2016, 07:00-10:00

ZORA's new graphical user interface will be relaunched (For further infos watch out slideshow ZORA: Neues Look & Feel). There will be short interrupts on ZORA Service between 07:00am and 10:00 am. Please be patient.

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-36195

Wirz, M. Predator or prey? : Chlamydophila abortus infections of a free-living amoebae, Acanthamoeba castellani 9GU. 2008, University of Zurich, Vetsuisse Faculty.

View at publisher


Limited evidence exists to suggest that the ability to invade and escape protozoan host cell bactericidal activity extends to members of the Chlamydiaceae, intracellular pathogens of humans and animals and evolutionary descendants of amoeba-resisting Chlamydia-like organisms. PCR and microscopic analyses of Chlamydophila abortus infections of Acanthamoeba castellani revealed uptake of this chlamydial pathogen but, unlike the well-described inhabitant of A. castellani, Parachlamydia acanthamoebae, Cp. abortus did not appear to propagate and is likely digested by its amoebal host. These data raise doubts about the ability of free-living amoebae to serve as hosts and vectors of pathogenic members of the Chlamydiaceae but reveal opportunities, via comparative genomics, to understand virulence mechanisms used by Chlamydia-like organisms to avoid amoebal digestion.


5 citations in Scopus®



97 downloads since deposited on 02 Dec 2010
14 downloads since 12 months

Detailed statistics

Additional indexing

Item Type:Dissertation
Referees:Vaughan L, Stephan R
Communities & Collections:05 Vetsuisse Faculty > Institute of Veterinary Pathology
Dewey Decimal Classification:570 Life sciences; biology
Deposited On:02 Dec 2010 11:45
Last Modified:05 Apr 2016 14:16
Additional Information:Predator or prey? : Chlamydophila abortus infections of a free-living amoebae, Acanthamoeba castellani 9GU / vorgelegt von Mirjam Wirz. - Zürich, 2008
Publisher DOI:10.1016/j.micinf.2008.01.006
Related URLs:http://opac.nebis.ch/F/?local_base=NEBIS&con_lng=GER&func=find-b&find_code=SYS&request=005948297
PubMed ID:18467146

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page