Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-36195
Wirz, M. Predator or prey? : Chlamydophila abortus infections of a free-living amoebae, Acanthamoeba castellani 9GU. 2008, University of Zurich, Vetsuisse Faculty.
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Limited evidence exists to suggest that the ability to invade and escape protozoan host cell bactericidal activity extends to members of the Chlamydiaceae, intracellular pathogens of humans and animals and evolutionary descendants of amoeba-resisting Chlamydia-like organisms. PCR and microscopic analyses of Chlamydophila abortus infections of Acanthamoeba castellani revealed uptake of this chlamydial pathogen but, unlike the well-described inhabitant of A. castellani, Parachlamydia acanthamoebae, Cp. abortus did not appear to propagate and is likely digested by its amoebal host. These data raise doubts about the ability of free-living amoebae to serve as hosts and vectors of pathogenic members of the Chlamydiaceae but reveal opportunities, via comparative genomics, to understand virulence mechanisms used by Chlamydia-like organisms to avoid amoebal digestion.
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|Referees:||Vaughan L, Stephan R|
|Communities & Collections:||05 Vetsuisse Faculty > Institute of Veterinary Pathology|
|Dewey Decimal Classification:||570 Life sciences; biology|
|Deposited On:||02 Dec 2010 11:45|
|Last Modified:||09 Jul 2012 04:28|
|Additional Information:||Predator or prey? : Chlamydophila abortus infections of a free-living amoebae, Acanthamoeba castellani 9GU / vorgelegt von Mirjam Wirz. - Zürich, 2008|
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