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Béchir, M; Enseleit, F; Chenevard, R; Lüscher, T F; Noll, G (2005). Effect of losartan on muscle sympathetic activity and baroreceptor function in systemic hypertension. American Journal of Cardiology, 95(1):129-131.

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Angiotensin II directly stimulates muscle sympathetic nerve activity and facilitates adrenergic sympathetic transmission. The hypotheses that the chronic blockade of angiotensin II receptors (AT(1) type) reduces muscle sympathetic activity and that there is an interaction with baroreceptor function in patients with mild to moderate hypertension were investigated. Muscle sympathetic nerve activity decreased from 51.7 +/- 3.5 to 45.9 +/- 4.2 bursts/min (p = 0.022), and cardiac baroreceptor sensitivity increased from 3.2 +/- 1.3 to 4.9 +/- 1.8 ms/mm Hg (p = 0.007). This study for the first time demonstrates that in hypertensive patients, chronic AT(1) receptor antagonism inhibits muscle sympathetic nerve activity and that baroreceptor function is improved under these conditions.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Cardiology
DDC:610 Medicine & health
Deposited On:03 Mar 2011 12:00
Last Modified:27 Nov 2013 21:05
Publisher DOI:10.1016/j.amjcard.2004.08.079
PubMed ID:15619411
Citations:Web of Science®. Times Cited: 10
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Scopus®. Citation Count: 11

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