Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive 

Riebler, A; Held, L; Stephan, W (2008). Bayesian variable selection for detecting adaptive genomic differences among populations. Genetics, 178(3):1817-1829.

Full text not available from this repository.

Abstract

We extend an F(st)-based Bayesian hierarchical model, implemented via Markov chain Monte Carlo, for the detection of loci that might be subject to positive selection. This model divides the F(st)-influencing factors into locus-specific effects, population-specific effects, and effects that are specific for the locus in combination with the population. We introduce a Bayesian auxiliary variable for each locus effect to automatically select nonneutral locus effects. As a by-product, the efficiency of the original approach is improved by using a reparameterization of the model. The statistical power of the extended algorithm is assessed with simulated data sets from a Wright-Fisher model with migration. We find that the inclusion of model selection suggests a clear improvement in discrimination as measured by the area under the receiver operating characteristic (ROC) curve. Additionally, we illustrate and discuss the quality of the newly developed method on the basis of an allozyme data set of the fruit fly Drosophila melanogaster and a sequence data set of the wild tomato Solanum chilense. For data sets with small sample sizes, high mutation rates, and/or long sequences, however, methods based on nucleotide statistics should be preferred.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Social and Preventive Medicine
DDC:610 Medicine & health
Language:English
Date:March 2008
Deposited On:09 Sep 2008 15:31
Last Modified:27 Nov 2013 17:35
Publisher:Genetics Society of America
ISSN:0016-6731
Publisher DOI:10.1534/genetics.107.081281
PubMed ID:18245358
Citations:Web of Science®. Times Cited: 31
Google Scholar™

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page