Spieker, L E; Ruschitzka, F; Lüscher, T F; Noll, G (2004). HDL and inflammation in atherosclerosis. Current Drug Targets. Immune, Endocrine & Metabolic Disorders, 4(1):51-57.
Full text not available from this repository.
View at publisher
Atherosclerotic vascular disease is among the most frequent causes of death worldwide. Current therapeutic strategies concentrate mainly on lowering of low-density lipoprotein (LDL) cholesterol and an impressive reduction in the risk for cardiovascular morbidity and mortality has been achieved. Inflammatory mechanisms are more and more recognized to play an important role in vascular disease as inflammatory markers correlate with prognosis in acute and chronic coronary artery disease. HDL cholesterol exerts anti-inflammatory effects on the vasculature. Moreover, HDL is an antioxidant, inhibits thrombogenesis, and has pro-fibrinolytic properties. Last but not least, HDL mediates reverse cholesterol transport. These pleiotropic effects make HDL an ideal therapeutic target for novel therapeutic strategies specifically aiming at HDL elevation for the prevention and treatment of atherosclerotic vascular disease.
0 downloads since deposited on 07 Mar 2011
0 downloads since 12 months
|Item Type:||Journal Article, refereed, further contribution|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Clinic for Cardiology|
|DDC:||610 Medicine & health|
|Deposited On:||07 Mar 2011 10:20|
|Last Modified:||23 Nov 2012 15:29|
Users (please log in): suggest update or correction for this item
Repository Staff Only: item control page