Quick Search:

uzh logo
Browse by:

Zurich Open Repository and Archive

Spieker, L E; Ruschitzka, F; Lüscher, T F; Noll, G (2004). HDL and inflammation in atherosclerosis. Current Drug Targets. Immune, Endocrine & Metabolic Disorders, 4(1):51-57.

Full text not available from this repository.

View at publisher


Atherosclerotic vascular disease is among the most frequent causes of death worldwide. Current therapeutic strategies concentrate mainly on lowering of low-density lipoprotein (LDL) cholesterol and an impressive reduction in the risk for cardiovascular morbidity and mortality has been achieved. Inflammatory mechanisms are more and more recognized to play an important role in vascular disease as inflammatory markers correlate with prognosis in acute and chronic coronary artery disease. HDL cholesterol exerts anti-inflammatory effects on the vasculature. Moreover, HDL is an antioxidant, inhibits thrombogenesis, and has pro-fibrinolytic properties. Last but not least, HDL mediates reverse cholesterol transport. These pleiotropic effects make HDL an ideal therapeutic target for novel therapeutic strategies specifically aiming at HDL elevation for the prevention and treatment of atherosclerotic vascular disease.



Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Cardiology
Dewey Decimal Classification:610 Medicine & health
Deposited On:07 Mar 2011 10:20
Last Modified:05 Apr 2016 14:17
Publisher:Bentham Science
Publisher DOI:10.2174/1568008043340044
PubMed ID:15032626

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page