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Spieker, L E; Ruschitzka, F; Lüscher, T F; Noll, G (2004). HDL and inflammation in atherosclerosis. Current Drug Targets. Immune, Endocrine & Metabolic Disorders, 4(1):51-57.

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Abstract

Atherosclerotic vascular disease is among the most frequent causes of death worldwide. Current therapeutic strategies concentrate mainly on lowering of low-density lipoprotein (LDL) cholesterol and an impressive reduction in the risk for cardiovascular morbidity and mortality has been achieved. Inflammatory mechanisms are more and more recognized to play an important role in vascular disease as inflammatory markers correlate with prognosis in acute and chronic coronary artery disease. HDL cholesterol exerts anti-inflammatory effects on the vasculature. Moreover, HDL is an antioxidant, inhibits thrombogenesis, and has pro-fibrinolytic properties. Last but not least, HDL mediates reverse cholesterol transport. These pleiotropic effects make HDL an ideal therapeutic target for novel therapeutic strategies specifically aiming at HDL elevation for the prevention and treatment of atherosclerotic vascular disease.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Cardiology
DDC:610 Medicine & health
Language:English
Date:2004
Deposited On:07 Mar 2011 10:20
Last Modified:23 Nov 2012 15:29
Publisher:Bentham Science
ISSN:1568-0088
Publisher DOI:10.2174/1568008043340044
PubMed ID:15032626

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