Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-36651

Schoenfeldt-Lecuona, C; Cardenas-Morales, L; Freudenmann, RW; Kammer, T; Herwig, U (2010). Transcranial magnetic stimulation in depression--lessons from the multicentre trials. Restorative Neurology and Neuroscience, 28(4):569-576.

[img]
Preview
PDF
1MB

View at publisher

Abstract

Looking at novelties and advances in medicine in particular in the treatment of major depressive disorder no principally new antidepressant treatment strategy has been established in clinical routine in the last fifty years. However, regarding the considerable issue of treatment resistance in depression, new therapeutic strategies are urgently required. In this context, repetitive transcranial magnetic stimulation above the dorsolateral prefrontal cortex has been proposed as a potential new treatment option for depression; furthermore, in October 2008 a first rTMS-device (NeuroStar TMS Therapy System™) was approved by the FDA for the treatment of treatment resistant major refractory depression in adults. Yet, despite now nearly two decades of research in this field, no final answer concerning its validity for antidepressant treatment in the clinical practice is given. Numerous studies with small sample sizes and heterogeneous designs have been performed in this field yielding to different results. These were subjected to meta-analyses, assessing the antidepressant effect of rTMS, which are briefly summarized in this article. Further, multicentre-trials with larger numbers of patients were performed, which are presented and critically discussed here in more detail. This short review shall thus provide an overview of the current status of knowledge concerning rTMS in depression and it also provides some recommendations for future research in this field.

Citations

17 citations in Web of Science®
20 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

72 downloads since deposited on 16 Dec 2010
31 downloads since 12 months

Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Psychiatric University Hospital Zurich > Clinic for Clinical and Social Psychiatry Zurich West (former)
DDC:610 Medicine & health
Language:English
Date:16 August 2010
Deposited On:16 Dec 2010 08:05
Last Modified:16 Jul 2014 19:09
Publisher:IOS Press
ISSN:0922-6028
Publisher DOI:10.3233/RNN-2010-0561

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page