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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-36732

Nieto, C; Almendinger, J; Gysi, S; Gómez-Orte, E; Kaech, A; Hengartner, M O; Schnabel, R; Moreno, S; Cabello, J (2010). ccz-1 mediates the digestion of apoptotic corpses in C. elegans. Journal of Cell Science, 123(12):2001-2007.

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Abstract

During development, the processes of cell division, differentiation and apoptosis must be precisely coordinated in order to maintain tissue homeostasis. The nematode C. elegans is a powerful model system in which to study cell death and its control. C. elegans apoptotic cells condense and form refractile corpses under differential interference contrast (DIC) microscopy. Activation of the GTPase CED-10 (Rac) in a neighbouring cell mediates the recognition and engulfment of the cell corpse. After inclusion of the engulfed corpse in a phagosome, different proteins are sequentially recruited onto this organelle to promote its acidification and fusion with lysosomes, leading to the enzymatic degradation of the cell corpse. We show that CCZ-1, a protein conserved from yeasts to humans, mediates the digestion of these apoptotic corpses. CCZ-1 seems to act in lysosome biogenesis and phagosome maturation by recruiting the GTPase RAB-7 over the phagosome.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Center for Microscopy and Image Analysis
07 Faculty of Science > Institute of Molecular Life Sciences
DDC:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2010
Deposited On:09 Nov 2010 16:23
Last Modified:28 Nov 2013 00:57
Publisher:Company of Biologists
ISSN:0021-9533
Publisher DOI:10.1242/jcs.062331
PubMed ID:20519582
Citations:Web of Science®. Times Cited: 9
Google Scholar™
Scopus®. Citation Count: 10

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