Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-36739
Saini, N; Schaffner, W (2010). Zinc supplement greatly improves the condition of parkin mutant Drosophila. Biological Chemistry, 391(5):513-518.
- Registered users only
View at publisher
Parkinson's disease (PD) is a progressive neurodegenerative disorder in which oxidative stress is implicated as a major causative factor. Mutations in the gene encoding Parkin, a ubiquitin ligase, are responsible for a familial form of PD. In a Drosophila disease model lacking Parkin (park(25) null mutant), we tested the effect of zinc supplementation. Zinc is an essential trace metal and a component of many enzymes and transcriptional regulators. Unlike copper and iron, zinc is not redox-active and under most conditions serves as an antioxidant. We find that the condition of parkin mutants raised on zinc-supplemented food is greatly improved. At zinc concentrations where controls begin to show adverse effects as a result of the metal supplement, parkin mutants perform best, as manifested in a higher frequency of reaching adulthood, extended lifespan and improved motoric abilities.
0 downloads since deposited on 09 Nov 2010
0 downloads since 12 months
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||07 Faculty of Science > Institute of Molecular Life Sciences|
|Dewey Decimal Classification:||570 Life sciences; biology|
|Deposited On:||09 Nov 2010 16:40|
|Last Modified:||20 Dec 2013 21:20|
Users (please log in): suggest update or correction for this item
Repository Staff Only: item control page