UZH-Logo

Maintenance Infos

Meet to fold: the peculiar folding of oligomeric proteins


Jelesarov, I; Karshikoff, A (2008). Meet to fold: the peculiar folding of oligomeric proteins. Biotechnology and Biotechnological Equipment, 22(1):598-605.

Abstract

Oligomeric proteins have been created as an evolutionary solution to fulfill specific cellular tasks, trading off functional and molecular requirements such as domain organization, molecular economy, minimization of the size of structural genes, reducing the costs for elimination of misfolded polypeptide chains, cooperativity, tight control, etc. Oligomers are also a challenging experimental object to test our concepts of the sequence-structure-energy-function relationships in proteins. In this paper, we briefly discuss the evolutionary aspects of the appearance of oligomers, and present with a few selected examples the current state of affairs in understanding the folding of small oligomeric proteins.

Oligomeric proteins have been created as an evolutionary solution to fulfill specific cellular tasks, trading off functional and molecular requirements such as domain organization, molecular economy, minimization of the size of structural genes, reducing the costs for elimination of misfolded polypeptide chains, cooperativity, tight control, etc. Oligomers are also a challenging experimental object to test our concepts of the sequence-structure-energy-function relationships in proteins. In this paper, we briefly discuss the evolutionary aspects of the appearance of oligomers, and present with a few selected examples the current state of affairs in understanding the folding of small oligomeric proteins.

Altmetrics

Downloads

3 downloads since deposited on 23 Sep 2008
0 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Department of Biochemistry
07 Faculty of Science > Department of Biochemistry
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:January 2008
Deposited On:23 Sep 2008 07:38
Last Modified:05 Apr 2016 12:28
Publisher:Diagnosis Press
ISSN:1310-2818
Publisher DOI:10.1080/13102818.2008.10817519
Official URL:http://www.diagnosisp.com/dp/journals/view_abstract.php?journal_id=1&archive=0&issue_id=17&article_id=470&PHPSESSID=58730fd4acdc37ccccbb8db4353f2544
Related URLs:http://www.diagnosisp.com/dp/journals/issue.php?journal_id=1&archive=0&issue_id=17&PHPSESSID=58730fd4acdc37ccccbb8db4353f2544 (Publisher)
Permanent URL: http://doi.org/10.5167/uzh-3733

Download

[img]
Content: Accepted Version
Filetype: PDF - Registered users only
Size: 1MB
View at publisher

TrendTerms

TrendTerms displays relevant terms of the abstract of this publication and related documents on a map. The terms and their relations were extracted from ZORA using word statistics. Their timelines are taken from ZORA as well. The bubble size of a term is proportional to the number of documents where the term occurs. Red, orange, yellow and green colors are used for terms that occur in the current document; red indicates high interlinkedness of a term with other terms, orange, yellow and green decreasing interlinkedness. Blue is used for terms that have a relation with the terms in this document, but occur in other documents.
You can navigate and zoom the map. Mouse-hovering a term displays its timeline, clicking it yields the associated documents.

Author Collaborations