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Gene duplications, robustness and evolutionary innovations


Wagner, A (2008). Gene duplications, robustness and evolutionary innovations. BioEssays, 30(4):367-373.

Abstract

Mutational robustness facilitates evolutionary innovations. Gene duplications are unique kinds of mutations, in that they generally increase such robustness. The frequent association of gene duplications in regulatory networks with evolutionary innovation is thus a special case of a general mechanism linking innovation to robustness. The potential power of this mechanism to promote evolutionary innovations on large time scales is illustrated here with several examples. These include the role of gene duplications in the vertebrate radiation, flowering plant evolution and heart development, which encompass some of the most striking innovations in the evolution of life.

Mutational robustness facilitates evolutionary innovations. Gene duplications are unique kinds of mutations, in that they generally increase such robustness. The frequent association of gene duplications in regulatory networks with evolutionary innovation is thus a special case of a general mechanism linking innovation to robustness. The potential power of this mechanism to promote evolutionary innovations on large time scales is illustrated here with several examples. These include the role of gene duplications in the vertebrate radiation, flowering plant evolution and heart development, which encompass some of the most striking innovations in the evolution of life.

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60 citations in Web of Science®
62 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Department of Biochemistry
07 Faculty of Science > Department of Biochemistry
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:March 2008
Deposited On:22 Sep 2008 07:47
Last Modified:05 Apr 2016 12:28
Publisher:Wiley-Blackwell
ISSN:0265-9247
Additional Information:The attached file is a preprint (accepted version) of an article published in BioEssays 30(4):367-373, 2008.
Publisher DOI:10.1002/bies.20728
PubMed ID:18348184
Permanent URL: http://doi.org/10.5167/uzh-3744

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