UZH-Logo

Maintenance Infos

Ex vivo evaluation of coronary atherosclerotic plaques: characterization with dual-source CT in comparison with histopathology


Leschka, S; Seitun, S; Dettmer, M; Baumüller, S; Stolzmann, P; Goetti, R; Scheffel, H; Feuchtner, G; Wunnicke, K; Wildermuth, S; Oehlschlegel, C; Marincek, B; Jochum, W; Alkadhi, H (2010). Ex vivo evaluation of coronary atherosclerotic plaques: characterization with dual-source CT in comparison with histopathology. Journal of Cardiovascular Computed Tomography, 4(5):301-308.

Abstract

BACKGROUND: Identification and differentiation of coronary atherosclerotic plaques may improve risk stratification for incident coronary events. OBJECTIVE: We investigated the ability of dual-source computed tomography (CT) to depict and characterize atherosclerotic coronary plaques. METHODS: Contrast-enhanced CT was performed in 25 human heart specimens with a total of 322 histologically determined plaques. Coronary plaques were classified on CT as (1) noncalcified, mixed, or calcified and (2) by CT attenuation values. Atherosclerotic plaques were histopathologically characterized according to the Stary classification. RESULTS: CT detected 79% (245/322) of all plaques. Lesions missed by CT were generally early lesions, type I (n = 31), type II (n = 38), or type III (n = 8), according to Stary. CT detected 29% of early (Stary I-III) and 100% of advanced (Stary IV-VIII) plaques. Plaque classification as noncalcified was sensitive (100%) and specific (72%) for early, whereas classification as mixed/calcified was sensitive (92%, 89%) and specific (100%) for advanced plaques. Calcified plaques on CT were detected with high sensitivity (80%) and specificity (95%). Other subtypes were not distinguishable with CT according to the presence or absence of calcification. CT density was significantly higher for advanced (306 ± 470 HU) than for early (42 ± 14 HU; P < 0.01) plaques. The mean CT density value of type VII plaques (512 ± 349 HU) was significantly higher than those of other plaques (34-101 HU; P < 0.001). CONCLUSIONS: CT reliably depicts advanced coronary plaques and allows for the differentiation between early and advanced plaques.

BACKGROUND: Identification and differentiation of coronary atherosclerotic plaques may improve risk stratification for incident coronary events. OBJECTIVE: We investigated the ability of dual-source computed tomography (CT) to depict and characterize atherosclerotic coronary plaques. METHODS: Contrast-enhanced CT was performed in 25 human heart specimens with a total of 322 histologically determined plaques. Coronary plaques were classified on CT as (1) noncalcified, mixed, or calcified and (2) by CT attenuation values. Atherosclerotic plaques were histopathologically characterized according to the Stary classification. RESULTS: CT detected 79% (245/322) of all plaques. Lesions missed by CT were generally early lesions, type I (n = 31), type II (n = 38), or type III (n = 8), according to Stary. CT detected 29% of early (Stary I-III) and 100% of advanced (Stary IV-VIII) plaques. Plaque classification as noncalcified was sensitive (100%) and specific (72%) for early, whereas classification as mixed/calcified was sensitive (92%, 89%) and specific (100%) for advanced plaques. Calcified plaques on CT were detected with high sensitivity (80%) and specificity (95%). Other subtypes were not distinguishable with CT according to the presence or absence of calcification. CT density was significantly higher for advanced (306 ± 470 HU) than for early (42 ± 14 HU; P < 0.01) plaques. The mean CT density value of type VII plaques (512 ± 349 HU) was significantly higher than those of other plaques (34-101 HU; P < 0.001). CONCLUSIONS: CT reliably depicts advanced coronary plaques and allows for the differentiation between early and advanced plaques.

Citations

14 citations in Web of Science®
19 citations in Scopus®
Google Scholar™

Altmetrics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Diagnostic and Interventional Radiology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2010
Deposited On:28 Dec 2010 09:45
Last Modified:05 Apr 2016 14:24
Publisher:Elsevier
ISSN:1876-861X
Publisher DOI:https://doi.org/10.1016/j.jcct.2010.05.016
PubMed ID:20947041

Download

Full text not available from this repository.View at publisher

TrendTerms

TrendTerms displays relevant terms of the abstract of this publication and related documents on a map. The terms and their relations were extracted from ZORA using word statistics. Their timelines are taken from ZORA as well. The bubble size of a term is proportional to the number of documents where the term occurs. Red, orange, yellow and green colors are used for terms that occur in the current document; red indicates high interlinkedness of a term with other terms, orange, yellow and green decreasing interlinkedness. Blue is used for terms that have a relation with the terms in this document, but occur in other documents.
You can navigate and zoom the map. Mouse-hovering a term displays its timeline, clicking it yields the associated documents.

Author Collaborations