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Control of transcription by Pontin and Reptin


Gallant, P (2007). Control of transcription by Pontin and Reptin. Trends in Cell Biology, 17(4):187-192.

Abstract

Pontin and Reptin are two closely related members of the AAA+ family of DNA helicases. They have roles in diverse cellular processes, including the response to DNA double-strand breaks and the control of gene expression. The two proteins share residence in different multiprotein complexes, such as the Tip60, Ino80, SRCAP and Uri1 complexes in animals, which are involved (directly or indirectly) in transcriptional regulation, but they also function independently from each other. Both Reptin and Pontin repress certain transcriptional targets of Myc, but only Reptin is required for the repression of specific ?-catenin and nuclear factor-?B targets. Here, I review recent studies that have addressed the mechanisms of transcriptional control by Pontin and Reptin.

Pontin and Reptin are two closely related members of the AAA+ family of DNA helicases. They have roles in diverse cellular processes, including the response to DNA double-strand breaks and the control of gene expression. The two proteins share residence in different multiprotein complexes, such as the Tip60, Ino80, SRCAP and Uri1 complexes in animals, which are involved (directly or indirectly) in transcriptional regulation, but they also function independently from each other. Both Reptin and Pontin repress certain transcriptional targets of Myc, but only Reptin is required for the repression of specific ?-catenin and nuclear factor-?B targets. Here, I review recent studies that have addressed the mechanisms of transcriptional control by Pontin and Reptin.

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70 citations in Web of Science®
73 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Zoology (former)
Dewey Decimal Classification:570 Life sciences; biology
590 Animals (Zoology)
Uncontrolled Keywords:transcription, chromatin, DNA helicase
Language:English
Date:April 2007
Deposited On:11 Feb 2008 12:14
Last Modified:05 Apr 2016 12:13
Publisher:Elsevier
ISSN:0962-8924
Publisher DOI:10.1016/j.tcb.2007.02.005
PubMed ID:17320397
Permanent URL: http://doi.org/10.5167/uzh-385

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