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Neumann, E; Lefèvre, S; Zimmermann, B; Gay, S; Müller-Ladner, U (2010). Rheumatoid arthritis progression mediated by activated synovial fibroblasts. Trends in Molecular Medicine, 16(10):458-468.

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Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovial hyperplasia and progressive joint destruction. Rheumatoid arthritis synovial fibroblasts (RASFs) are leading cells in joint erosion and contribute actively to inflammation. RASFs show an activated phenotype that is independent of the inflammatory environment and requires the combination of several factors. Although new aspects regarding RASF activation via matrix degradation products, epigenetic modifications, inflammatory factors, Toll-like receptor (TLR) activation and others have recently been uncovered, the primary pathophysiological processes in early arthritis leading to permanent activation are mostly unknown. Here, we review new findings regarding RASF activation and their altered behavior that contribute to matrix destruction and inflammation as well as their potential to spread RA.


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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Rheumatology Clinic and Institute of Physical Medicine
Dewey Decimal Classification:610 Medicine & health
Deposited On:24 Nov 2010 16:47
Last Modified:27 Nov 2013 16:55
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:10.1016/j.molmed.2010.07.004
PubMed ID:20739221

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