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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-38601

Rohrmann, S; Linseisen, J; Jakobsen, M U; Overvad, K; Raaschou-Nielsen, O; Tjonneland, A; Boutron-Ruault, M C; Kaaks, R; Becker, N; Bergmann, M; Boeing, H; Khaw, K T; Wareham, N J; Key, T J; Travis, R; Benetou, V; Naska, A; Trichopoulou, A; Pala, V; Tumino, R; Masala, G; Mattiello, A; Brustad, M; Lund, E; Skeie, G; Bueno-de-Mesquita, H B; Peeters, P H; Vermeulen, R C H; Jakszyn, P; Dorronsoro, M; Barricarte, A; Tormo, M J; Molina, E; Argüelles, M; Melin, B; Ericson, U; Manjer, J; Rinaldi, S; Slimani, N; Boffetta, P; Vergnaud, A C; Khan, A; Norat, T; Vineis, P (2011). Consumption of meat and dairy and lymphoma risk in the european prospective investigation into cancer and nutrition. International Journal of Cancer, 128(3):623-634.

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Abstract

The consumption of meat and other foods of animal origin is a risk factor for several types of cancer, but the results for lymphomas are inconclusive. Therefore, we examined these associations among 411,097 participants of the European Prospective Investigation into Cancer and Nutrition (EPIC). During a median follow-up of 8.5 years, 1334 lymphomas (1,267 non-Hodgkin lymphoma, 67 Hodgkin lyphomas) were identified. Consumption of red and processed meat, poultry, milk, and dairy products was assessed by dietary questionnaires. Cox proportional hazard regression was used to evaluate the association of the consumption of these food groups with lymphoma risk. Overall, consumption of foods of animal origin were not associated with an increased risk of NHL or HL, but associations with specific subgroups of NHL entities were noted. A high intake of processed meat was associated with an increased risk of B-cell chronic lymphocytic leukaemia (BCLL) (relative risk (RR) per 50 g intake = 1.31, 95% confidence interval (CI) 1.06-1.63), but a decreased risk of follicular lymphomas (FL) (RR=0.58; 0.38-0.89). A high intake of poultry was related to an increased risk of B-cell lymphomas (RR=1.22, 1.05-1.42 per 10 g intake), FL (RR=1.65; 1.18-2.32), and BCLL (RR=1.54; 1.18-2.01) in the continuous models. In conclusion, no consistent associations between red and processed meat consumption and lymphoma risk were observed, but we found that the consumption of poultry was related to an increased risk of B-cell lymphomas. Chance is a plausible explanation of the observed associations, which need to be confirmed in further studies.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Social and Preventive Medicine
DDC:610 Medicine & health
Language:English
Date:14 April 2011
Deposited On:17 Jan 2011 09:08
Last Modified:29 Nov 2013 21:55
Publisher:Wiley-Blackwell
ISSN:0020-7136
Publisher DOI:10.1002/ijc.25387
PubMed ID:20473877
Citations:Web of Science®. Times Cited: 7
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