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Garbi, Natalio; Hämmerling, Günter J; Probst, Hans C; van den Broek, Maries (2010). Tonic T cell signalling and T cell tolerance as opposite effects of self-recognition on dendritic cells. Current Opinion in Immunology, 22(5):601-608.

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Naive T cells spend most of their time scanning the surface of dendritic cells (DCs), indicating that self-MHC/T cell receptor (TCR) interactions between these immune cells occur routinely in peripheral organs during the steady state. Peripheral self-MHC recognition on DCs drives seemingly opposing effects in the absence of inflammatory stimuli such as deletion of certain self-reactive T cells as well as maintenance of the T cell responsiveness to antigen, both of which shape the T cell repertoire and regulate T cell responses. Here we review recent data on the role of self-MHC recognition on steady-state DCs in the periphery and propose that interactions between T cells and steady-state DCs display an analogy with selection processes that occur in the thymus: high affinity TCR/self-MHC interactions in the periphery result in T cell deletion, while low/intermediate affinity interactions result in tonic TCR signalling that is required to keep T cells responsive to antigen.


21 citations in Web of Science®
22 citations in Scopus®
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Additional indexing

Other titles:
Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Oncology
Dewey Decimal Classification:610 Medicine & health
Date:October 2010
Deposited On:18 Jan 2011 11:18
Last Modified:05 Apr 2016 14:25
Publisher DOI:10.1016/j.coi.2010.08.007
PubMed ID:20880686

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