Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive 

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-38682

Gabi, M; Hefermehl, L; Lukic, D; Zahn, R; Vörös, J; Eberli, D (2011). Electrical microcurrent to prevent conditioning film and bacterial adhesion to urological stents. Urological Research, 39(2):81-88.

[img] PDF - Registered users only
478kB

Abstract

Long-term catheters remain a significant clinical problem in urology due to the high rate of bacterial colonization, infection, and encrustation. Minutes after insertion of a catheter, depositions of host urinary components onto the catheter surface form a conditioning film actively supporting the bacterial adhesion process. We investigated the possibility of reducing or avoiding the buildup of these naturally forming conditioning films and of preventing bacterial adhesion by applying different current densities to platinum electrodes as a possible catheter coating material. In this model we employed a defined environment using artificial urine and Proteus mirabilis. The film formation and desorption was analyzed by highly mass sensitive quartz crystal microbalance and surface sensitive atomic force microscopy. Further, we performed bacterial staining to assess adherence, growth, and survival on the electrodes with different current densities. By applying alternating microcurrent densities on platinum electrodes, we could produce a self regenerative surface which actively removed the conditioning film and significantly reduced bacterial adherence, growth, and survival. The results of this study could easily be adapted to a catheter design for clinical use.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Division of Surgical Research
04 Faculty of Medicine > University Hospital Zurich > Urological Clinic
04 Faculty of Medicine > Institute of Biomedical Engineering
DDC:170 Ethics
610 Medicine & health
Language:English
Date:2011
Deposited On:06 Jan 2011 15:27
Last Modified:09 Dec 2013 12:27
Publisher:Springer
ISSN:0300-5623
Publisher DOI:10.1007/s00240-010-0284-3
PubMed ID:20686759
Citations:Web of Science®. Times Cited: 4
Google Scholar™
Scopus®. Citation Count: 6

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page