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Wollmann, G; et al,; Berger, W (2006). Voltage-dependent ion channels in the mouse RPE: comparison with Norrie disease mice. Vision Research, 46(5):688-698.

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Abstract

We studied electrophysiological properties of cultured retinal pigment epithelial (RPE) cells from mouse and a mouse model for Norrie disease. Wild-type RPE cells revealed the expression of ion channels known from other species: delayed-rectifier K(+) channels composed of Kv1.3 subunits, inward rectifier K(+) channels, Ca(V)1.3 L-type Ca(2+) channels and outwardly rectifying Cl(-) channels. Expression pattern and the ion channel characteristics current density, blocker sensitivity, kinetics and voltage-dependence were compared in cells from wild-type and Norrie mice. Although no significant differences were observed, our study provides a base for future studies on ion channel function and dysfunction in transgenic mouse models.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Medical Molecular Genetics
DDC:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2006
Deposited On:03 Mar 2011 12:46
Last Modified:27 Nov 2013 19:13
Publisher:Elsevier
ISSN:0042-6989
Publisher DOI:10.1016/j.visres.2005.08.030
PubMed ID:16289664
Citations:Web of Science®. Times Cited: 11
Google Scholar™
Scopus®. Citation Count: 11

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