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Systemic and cellular reflections on ageing and the circadian oscillator - A mini-review


Brown, S A; Pagani, L; Cajochen, C; Eckert, A (2011). Systemic and cellular reflections on ageing and the circadian oscillator - A mini-review. Gerontology, 57(5):427-434.

Abstract

From circulation to digestion to excretion, a circadian clock synchronizes most aspects of mammalian physiology with the solar day. During normal ageing, this daily coordination gradually erodes, and during pathological ageing such erosion is exacerbated. Recent experiments suggest that therapies aimed at sustaining circadian function increase quality of life in elderly patients. Hence, a better understanding of the interactions between the circadian clock and ageing - at both cellular and systemic levels - could lead to direct benefits for aged individuals.

From circulation to digestion to excretion, a circadian clock synchronizes most aspects of mammalian physiology with the solar day. During normal ageing, this daily coordination gradually erodes, and during pathological ageing such erosion is exacerbated. Recent experiments suggest that therapies aimed at sustaining circadian function increase quality of life in elderly patients. Hence, a better understanding of the interactions between the circadian clock and ageing - at both cellular and systemic levels - could lead to direct benefits for aged individuals.

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12 citations in Web of Science®
12 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Institute of Pharmacology and Toxicology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2011
Deposited On:10 Jan 2011 09:47
Last Modified:24 Jun 2016 13:05
Publisher:Karger
ISSN:0304-324X
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:10.1159/000320673
PubMed ID:20980722
Permanent URL: http://doi.org/10.5167/uzh-39517

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