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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-3953

Seidl, K; Bischoff, M; Berger-Bächi, B (2008). CcpA mediates the catabolite repression of tst in Staphylococcus aureus. Infection and Immunity, 76(11):5093-5099.

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Some clinical isolates of Staphylococcus aureus produce the superantigenic toxic shock syndrome toxin TSST-1, encoded by tst and located on pathogenicity islands. The expression of tst is complex, and influenced by environmental conditions such as pH, CO2 and glucose. We identified a putative catabolite responsive element (cre) in the promoter region of all known tst genes, indicating that tst transcription may be regulated by the catabolite control protein CcpA. By introducing tst-genes under their native promoter or tst-promoter-reporter gene fusions in wild type strain Newman, we showed that glucose was able to repress tst transcription and TSST-1 production, whereas glucose repression was abolished in the corresponding DeltaccpA mutant. Stabilizing the pH ruled out a pH effect due to acid production during glucose catabolism. CcpA thus directly regulates tst transcription, linking carbohydrate utilization to virulence gene expression in S. aureus.


22 citations in Web of Science®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Medical Microbiology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Date:18 August 2008
Deposited On:06 Nov 2008 13:54
Last Modified:05 Apr 2016 12:28
Publisher:American Society for Microbiology
Additional Information:Copyright: American Society for Microbiology
Publisher DOI:10.1128/IAI.00724-08
PubMed ID:18710862

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