Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-39538

Milde, F; Bergdorf, M; Koumoutsakos, P (2008). A hybrid model for three-dimensional simulations of sprouting angiogenesis. Biophysical journal, 95(7):3146-60.

[img]
Preview
PDF
1MB

View at publisher

Abstract

Recent advances in cancer research have identified critical angiogenic signaling pathways and the influence of the extracellular matrix on endothelial cell migration. These findings provide us with insight into the process of angiogenesis that can facilitate the development of effective computational models of sprouting angiogenesis. In this work, we present the first three-dimensional model of sprouting angiogenesis that considers explicitly the effect of the extracellular matrix and of the soluble as well as matrix-bound growth factors on capillary growth. The computational model relies on a hybrid particle-mesh representation of the blood vessels and it introduces an implicit representation of the vasculature that can accommodate detailed descriptions of nutrient transport. Extensive parametric studies reveal the role of the extracellular matrix structure and the distribution of the different vascular endothelial growth factors isoforms on the dynamics and the morphology of the generated vascular networks.

Citations

41 citations in Web of Science®
37 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

67 downloads since deposited on 26 Nov 2010
17 downloads since 12 months

Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:Special Collections > SystemsX.ch
Special Collections > SystemsX.ch > Research, Technology and Development Projects > WingX
DDC:570 Life sciences; biology
Language:English
Date:2008
Deposited On:26 Nov 2010 15:01
Last Modified:28 Nov 2013 01:06
Publisher:Biophysical Society
ISSN:0006-3495
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:10.1529/biophysj.107.124511
PubMed ID:18586846

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page