Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-3960

Biber, J; Hernando, N; Forster, I; Murer, H (2009). Regulation of phosphate transport in proximal tubules. Pflügers Archiv: European Journal of Physiology (Pflugers Archiv), 458(1):39-52.

[img] PDF - Registered users only
1MB

View at publisher

Abstract

Homeostasis of inorganic phosphate (P(i)) is primarily an affair of the kidneys. Reabsorption of the bulk of filtered P(i) occurs along the renal proximal tubule and is initiated by apically localized Na(+)-dependent P(i) cotransporters. Tubular P(i) reabsorption and therefore renal excretion of P(i) is controlled by a number of hormones, including phosphatonins, and metabolic factors. In most cases, regulation of P(i) reabsorption is achieved by changing the apical abundance of Na(+)/Pi cotransporters. The regulatory mechanisms involve various signaling pathways and a number of proteins that interact with Na(+)/P(i) cotransporters.

Citations

71 citations in Web of Science®
70 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

6 downloads since deposited on 07 Oct 2008
0 downloads since 12 months

Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Center for Integrative Human Physiology
04 Faculty of Medicine > Institute of Physiology
07 Faculty of Science > Institute of Physiology
DDC:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2009
Deposited On:07 Oct 2008 10:56
Last Modified:27 Nov 2013 16:22
Publisher:Springer
ISSN:0031-6768
Additional Information:The original publication is available at www.springerlink.com
Publisher DOI:10.1007/s00424-008-0580-8
PubMed ID:18758808

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page