Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive 

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-39665

Bestmann, S; Swayne, O; Blankenburg, F; Ruff, Christian C; Teo, J; Weiskopf, N; Driver, J; Rothwell, J C; Ward, N S (2010). The role of contralesional dorsal premotor cortex after stroke as studied with concurrent TMS-fMRI. Journal of Neuroscience, 30(36):11926-11937.

[img]
Preview
PDF (Verlags-PDF)
1MB

Abstract

Contralesional dorsal premotor cortex (cPMd) may support residual motor function following stroke. We performed two complementary experiments to explore how cPMd might perform this role in a group of chronic human stroke patients. First, we used paired-coil transcranial magnetic stimulation (TMS) to establish the physiological influence of cPMd on ipsilesional primary motor cortex (iM1) at rest. We found that this influence became less inhibitory/more facilitatory in patients with greater clinical impairment. Second, we applied TMS over cPMd during functional magnetic resonance imaging (fMRI) in these patients to examine the causal influence of cPMd TMS on the whole network of surviving cortical motor areas in either hemisphere and whether these influences changed during affected hand movement. We confirmed that hand grip-related activation in cPMd was greater in more impaired patients. Furthermore, the peak ipsilesional sensorimotor cortex activity shifted posteriorly in more impaired patients. Critical new findings were that concurrent TMS-fMRI results correlated with the level of both clinical impairment and neurophysiological impairment (i.e., less inhibitory/more facilitatory cPMd-iM1 measure at rest as assessed with paired-coil TMS). Specifically, greater clinical and neurophysiological impairment was associated with a stronger facilitatory influence of cPMd TMS on blood oxygenation level-dependent signal in posterior parts of ipsilesional sensorimotor cortex during hand grip, corresponding to the posteriorly shifted sensorimotor activity seen in more impaired patients. cPMd TMS was not found to influence activity in other brain regions in either hemisphere. This state-dependent influence on ipsilesional sensorimotor regions may provide a mechanism by which cPMd supports recovered function after stroke.

Item Type:Journal Article, refereed, original work
Communities & Collections:03 Faculty of Economics > Department of Economics
08 University Research Priority Programs > Foundations of Human Social Behavior: Altruism and Egoism
DDC:170 Ethics
330 Economics
Language:English
Date:2010
Deposited On:12 Jan 2011 08:28
Last Modified:27 Nov 2013 21:02
Publisher:Society for Neuroscience
ISSN:0270-6474
Publisher DOI:10.1523/JNEUROSCI.5642-09.2010
PubMed ID:20826657
Citations:Web of Science®. Times Cited: 32
Google Scholar™
Scopus®. Citation Count: 29

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page