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Nonlinear dynamic causal models for fMRI


Stephan, K E; Kasper, L; Harrison, L M; Daunizeau, J; den Ouden, H E M; Breakspear, M; Friston, K J (2008). Nonlinear dynamic causal models for fMRI. NeuroImage, 42(2):649-662.

Abstract

Models of effective connectivity characterize the influence that neuronal populations exert over each other. Additionally, some approaches, for example Dynamic Causal Modelling (DCM) and variants of Structural Equation Modelling, describe how effective connectivity is modulated by experimental manipulations. Mathematically, both are based on bilinear equations, where the bilinear term models
the effect of experimental manipulations on neuronal interactions. The bilinear framework, however, precludes an important aspect of neuronal interactions that has been established with invasive electrophysiological recording studies; i.e., how the connection between two neuronal units is enabled or gated by activity in other units. These gating processes are critical for controlling the gain of
neuronal populations and are mediated through interactions between synaptic inputs (e.g. by means of voltage-sensitive ion channels). They represent a key mechanism for various neurobiological processes, including top-down (e.g. attentional) modulation, learning and neuromodulation.
This paper presents a nonlinear extension of DCM that models such processes (to second order) at the
neuronal population level. In this way, the modulation of network interactions can be assigned to an explicit neuronal population. We present simulations and empirical results that demonstrate the validity and usefulness of this model. Analyses of synthetic data showed that nonlinear and bilinear mechanisms can be distinguished by our extended DCM. When applying the model to empirical fMRI
data from a blocked attention to motion paradigm, we found that attention-induced increases in V5 responses could be best explained as a gating of the V1→V5 connection by activity in posterior parietal cortex. Furthermore, we analysed fMRI data from an event-related binocular rivalry paradigm and found that interactions amongst percept-selective visual areas were modulated by activity in the
middle frontal gyrus. In both practical examples, Bayesian model selection favoured the nonlinear models over corresponding bilinear ones.

Models of effective connectivity characterize the influence that neuronal populations exert over each other. Additionally, some approaches, for example Dynamic Causal Modelling (DCM) and variants of Structural Equation Modelling, describe how effective connectivity is modulated by experimental manipulations. Mathematically, both are based on bilinear equations, where the bilinear term models
the effect of experimental manipulations on neuronal interactions. The bilinear framework, however, precludes an important aspect of neuronal interactions that has been established with invasive electrophysiological recording studies; i.e., how the connection between two neuronal units is enabled or gated by activity in other units. These gating processes are critical for controlling the gain of
neuronal populations and are mediated through interactions between synaptic inputs (e.g. by means of voltage-sensitive ion channels). They represent a key mechanism for various neurobiological processes, including top-down (e.g. attentional) modulation, learning and neuromodulation.
This paper presents a nonlinear extension of DCM that models such processes (to second order) at the
neuronal population level. In this way, the modulation of network interactions can be assigned to an explicit neuronal population. We present simulations and empirical results that demonstrate the validity and usefulness of this model. Analyses of synthetic data showed that nonlinear and bilinear mechanisms can be distinguished by our extended DCM. When applying the model to empirical fMRI
data from a blocked attention to motion paradigm, we found that attention-induced increases in V5 responses could be best explained as a gating of the V1→V5 connection by activity in posterior parietal cortex. Furthermore, we analysed fMRI data from an event-related binocular rivalry paradigm and found that interactions amongst percept-selective visual areas were modulated by activity in the
middle frontal gyrus. In both practical examples, Bayesian model selection favoured the nonlinear models over corresponding bilinear ones.

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184 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:03 Faculty of Economics > Department of Economics
Dewey Decimal Classification:330 Economics
Language:English
Date:August 2008
Deposited On:01 Oct 2008 13:30
Last Modified:05 Apr 2016 12:28
Publisher:Elsevier
ISSN:1053-8119
Publisher DOI:10.1016/j.neuroimage.2008.04.262
Permanent URL: http://doi.org/10.5167/uzh-3971

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