Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-39783
Kalapala, S K; Hobbie, S N; Böttger, E C; Shcherbakov, D (2010). Mutation K42R in ribosomal protein S12 does not affect susceptibility of Mycobacterium smegmatis 16S rRNA A-site mutants to 2-deoxystreptamines. PLoS ONE, 5(9):e11960.
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Abstract
Recent studies have suggested that ribosomal protein S12 modulates 16S rRNA function and susceptibility to 2-deoxystreptamine aminoglycosides. To study whether the non-restrictive K42R mutation in RpsL affects 2-deoxystreptamine susceptibility in Mycobacterium smegmatis, we studied the drug susceptibility pattern of various mutants with genetic alterations in the 16S rRNA decoding A-site in the context of wild-type and mutant protein S12. RpsL K42R substitution was found not to affect the drug resistance pattern associated with mutational alterations in 16S rRNA H44.
| Item Type: | Journal Article, refereed, original work |
|---|---|
| Communities & Collections: | 04 Faculty of Medicine > Institute of Medical Microbiology |
| DDC: | 570 Life sciences; biology 610 Medicine & health |
| Language: | English |
| Date: | 2010 |
| Deposited On: | 11 Jan 2011 19:47 |
| Last Modified: | 23 Nov 2012 14:32 |
| Publisher: | Public Library of Science |
| ISSN: | 1932-6203 |
| Free access at: | Publisher DOI. An embargo period may apply. |
| Publisher DOI: | 10.1371/journal.pone.0011960 |
| PubMed ID: | 20700526 |
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