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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-39783

Kalapala, S K; Hobbie, S N; Böttger, E C; Shcherbakov, D (2010). Mutation K42R in ribosomal protein S12 does not affect susceptibility of Mycobacterium smegmatis 16S rRNA A-site mutants to 2-deoxystreptamines. PLoS ONE, 5(9):e11960.



Recent studies have suggested that ribosomal protein S12 modulates 16S rRNA function and susceptibility to 2-deoxystreptamine aminoglycosides. To study whether the non-restrictive K42R mutation in RpsL affects 2-deoxystreptamine susceptibility in Mycobacterium smegmatis, we studied the drug susceptibility pattern of various mutants with genetic alterations in the 16S rRNA decoding A-site in the context of wild-type and mutant protein S12. RpsL K42R substitution was found not to affect the drug resistance pattern associated with mutational alterations in 16S rRNA H44.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Medical Microbiology
DDC:570 Life sciences; biology
610 Medicine & health
Deposited On:11 Jan 2011 18:47
Last Modified:27 Nov 2013 22:55
Publisher:Public Library of Science
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:10.1371/journal.pone.0011960
PubMed ID:20700526
Citations:Web of Science®. Times Cited: 1
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Scopus®. Citation Count: 1

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