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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-39837

Fuhrer, A; Sprenger, N; Kurakevich, E; Borsig, L; Chassard, C; Hennet, T (2010). Milk sialyllactose influences colitis in mice through selective intestinal bacterial colonization. Journal of Experimental Medicine, 207(13):2843-2854.

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Abstract

Milk oligosaccharides contribute to the development of the intestinal environment by acting as decoy receptors for pathogens and as prebiotics, which promote the colonization of commensal bacteria. Here, using α2,3- and α2,6-sialyltransferase-deficient mice, we investigated the role of the sialylated milk oligosaccharides sialyl(α2,3)lactose and sialyl(α2,6)lactose on mucosal immunity. The exposure of newborn mice to milk containing or deficient in sialyllactose had no impact on the development of mucosal leukocyte populations. However, when challenged by dextran sulfate sodium (DSS) in drinking water, adult mice that had been fostered on sialyl(α2,3)lactose-deficient milk were more resistant to colitis compared with mice fostered on normal milk or sialyl(α2,6)lactose-deficient milk. Analysis of intestinal microbiota showed different colonization patterns depending on the presence or absence of sialyl(α2,3)lactose in the milk. Germ-free mice reconstituted with intestinal microbiota isolated from mice fed on sialyl(α2,3)lactose-deficient milk were more resistant to DSS-induced colitis than germ-free mice reconstituted with standard intestinal microbiota. Thus, exposure to sialyllactose during infancy affects bacterial colonization of the intestine, which influences the susceptibility to DSS-induced colitis in adult mice.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Physiology
07 Faculty of Science > Institute of Physiology

04 Faculty of Medicine > Center for Integrative Human Physiology
DDC:570 Life sciences; biology
610 Medicine & health
Language:English
Date:22 November 2010
Deposited On:21 Jan 2011 14:02
Last Modified:19 Jul 2014 16:16
Publisher:Rockefeller University Press
ISSN:0022-1007
Publisher DOI:10.1084/jem.20101098
PubMed ID:21098096
Citations:Web of Science®. Times Cited: 23
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Scopus®. Citation Count: 23

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