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Prion protein and Abeta-related synaptic toxicity impairment


Calella, A M; Farinelli, M; Nuvolone, M; Mirante, O; Moos, R; Falsig, J; Mansuy, I M; Aguzzi, A (2010). Prion protein and Abeta-related synaptic toxicity impairment. EMBO Molecular Medicine, 2(8):306-314.

Abstract

Alzheimer's disease (AD), the most common neurodegenerative disorder, goes along with extracellular amyloid-beta (Abeta) deposits. The cognitive decline observed during AD progression correlates with damaged spines, dendrites and synapses in hippocampus and cortex. Numerous studies have shown that Abeta oligomers, both synthetic and derived from cultures and AD brains, potently impair synaptic structure and functions. The cellular prion protein (PrP(C)) was proposed to mediate this effect. We report that ablation or overexpression of PrP(C) had no effect on the impairment of hippocampal synaptic plasticity in a transgenic model of AD. These findings challenge the role of PrP(C) as a mediator of Abeta toxicity.

Alzheimer's disease (AD), the most common neurodegenerative disorder, goes along with extracellular amyloid-beta (Abeta) deposits. The cognitive decline observed during AD progression correlates with damaged spines, dendrites and synapses in hippocampus and cortex. Numerous studies have shown that Abeta oligomers, both synthetic and derived from cultures and AD brains, potently impair synaptic structure and functions. The cellular prion protein (PrP(C)) was proposed to mediate this effect. We report that ablation or overexpression of PrP(C) had no effect on the impairment of hippocampal synaptic plasticity in a transgenic model of AD. These findings challenge the role of PrP(C) as a mediator of Abeta toxicity.

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Additional indexing

Other titles:Prion protein and Aβ‐related synaptic toxicity impairment
Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Neuropathology
04 Faculty of Medicine > Brain Research Institute
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2010
Deposited On:19 Jan 2011 13:24
Last Modified:17 Aug 2016 09:05
Publisher:Wiley Open Access
ISSN:1757-4676
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:10.1002/emmm.201000082
PubMed ID:20665634
Permanent URL: http://doi.org/10.5167/uzh-39973

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