Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-39986
Ligios, C; Cancedda, M G; Carta, A; Santucciu, C; Maestrale, C; Demontis, F; Sabat, M; Patta, C; Demartini, J C; Aguzzi, A; Sigurdson, C J (2011). Sheep with scrapie and mastitis transmit infectious prions through the milk. Journal of Virology, 85(2):1136-1139.
Prions are misfolded proteins that are infectious and naturally transmitted, causing a fatal neurological disease in humans and animals. Prion shedding routes have been shown to be modified by inflammation in excretory organs such as kidney. Here we show that sheep with scrapie and lentiviral mastitis secrete prions into the milk and infect nearly 90% of suckling naive lambs. Thus lentiviruses may enhance prion transmission, conceivably sustaining prion infections in flocks for generations. This study also indicates a risk of prion spread to sheep and potentially to other animals through dietary exposure to pooled sheep milk or milk products.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Institute of Neuropathology|
|DDC:||570 Life sciences; biology
610 Medicine & health
|Deposited On:||15 Jan 2011 16:07|
|Last Modified:||27 Nov 2013 17:09|
|Publisher:||American Society for Microbiology|
|Free access at:||PubMed ID. An embargo period may apply.|
|Citations:||Web of Science®. Times Cited: 20|
Scopus®. Citation Count: 21
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