Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-39995

Pavik, I; Jaeger, P; Kistler, A D; Poster, D; Krauer, F; Cavelti-Weder, C; Rentsch, K M; Wüthrich, R P; Serra, A L (2011). Patients with autosomal dominant polycystic kidney disease have elevated fibroblast growth factor 23 levels and a renal leak of phosphate. Kidney International, 79(2):234-240.

[img] PDF (Verlags-PDF) - Registered users only
1MB

View at publisher
[img]
Preview
Accepted Version
PDF
151kB

Abstract

Fibroblast growth factor 23 (FGF23) and parathyroid hormone blood levels rise following progressive loss of renal function. Here we measured parameters of phosphate metabolism in 100 patients with autosomal dominant polycystic kidney disease (ADPKD) in stage 1 or 2 of chronic kidney disease, 20 patients with non-diabetic chronic kidney disease, and 26 with type 2 diabetes. Twenty healthy volunteers served as controls. The mean levels of FGF23 were significantly (4-fold) higher in ADPKD compared to non-diabetic and diabetic patients, and healthy volunteers. Mean serum phosphate levels were significantly lower in ADPKD patients compared to non-diabetic and diabetic patients, and the healthy volunteers. The prevalence of hypophosphatemia was 38, 25, 27, and 5% in ADPKD, non-diabetic and diabetic patients, and healthy volunteers, respectively. The tubular maximum of phosphate reabsorption per glomerular filtration rate was lowest in ADPKD patients with a significantly high positive correlation with serum phosphate levels. Estimated glomerular filtration rates were approximately 100 ml/min per 1.73 m(2) in all groups and parathyroid hormone and vitamin D metabolite levels were in the normal range. Thus, FGF23 was substantially elevated in ADPKD patients compared to other CKD patients matched for glomerular filtration rate, and was associated with increased renal phosphate excretion. The mechanism for this anomaly will require further study.

Citations

20 citations in Web of Science®
22 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

68 downloads since deposited on 11 Jan 2011
18 downloads since 12 months

Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Nephrology
04 Faculty of Medicine > University Hospital Zurich > Institute of Clinical Chemistry
04 Faculty of Medicine > Institute of Physiology
07 Faculty of Science > Institute of Physiology

04 Faculty of Medicine > Center for Integrative Human Physiology
DDC:570 Life sciences; biology
610 Medicine & health
540 Chemistry
Language:English
Date:2011
Deposited On:11 Jan 2011 15:15
Last Modified:27 Nov 2013 17:32
Publisher:Nature Publishing Group
ISSN:0085-2538
Additional Information:Accepted manuscript u.d.T.: Elevated FGF23 levels in ADPKD patients with apparent renal leak of phosphate: A new manifestation of ADPKD.
Publisher DOI:10.1038/ki.2010.375
PubMed ID:20944552

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page