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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-40291

Vellekoop, I M; Aegerter, C M (2010). Focusing light through living tissue. In: Optical coherence tomography and coherence domain optical methods in biomedicine XIV, San Francisco, CA, USA, 25 January 2010 - 27 January 2010, 755430 (10 pp.).

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Tissues such as skin, fat or cuticle are non-transparent because inhomogeneities in the tissue scatter light. We demonstrate experimentally that light can be focused through turbid layers of living tissue, in spite of scattering. Our method is based on the fact that coherent light forms an interference pattern, even after hundreds of scattering events. By spatially shaping the wavefront of the incident laser beam, this interference pattern was modified to make the scattered light converge to a focus. In contrast to earlier experiments, where light was focused through solid objects, we focused light through living pupae of Drosophila melanogaster. We discuss a dynamic wavefront shaping algorithm that follows changes due to microscopic movements of scattering particles in real time. We relate the performance of the algorithm to the measured timescale of the changes in the speckle pattern and analyze our experiment in the light of Laser Doppler flowmetry. Applications in particle tracking, imaging, and optical manipulation are discussed.


19 citations in Web of Science®
23 citations in Scopus®
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22 downloads since deposited on 15 Dec 2010
8 downloads since 12 months

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Additional indexing

Item Type:Conference or Workshop Item (Paper), refereed, original work
Communities & Collections:07 Faculty of Science > Physics Institute
Special Collections > SystemsX.ch
Special Collections > SystemsX.ch > Research, Technology and Development Projects > WingX
Dewey Decimal Classification:570 Life sciences; biology
530 Physics
Uncontrolled Keywords:Practical, Experimental/ biological techniques; biological tissues; biomedical optical imaging; bio-optics; light interference; optical focusing/ light focusing; living tissue; skin; fat; cuticle; turbidity; interference pattern; spatial wavefront shaping; Drosophila melanogaster; Laser Doppler flowmetry; particle tracking; particle imaging; optical manipulation/ A8750B Interactions of biosystems with radiations; A8760F Optical and laser radiation (medical uses); A8780 Biophysical instrumentation and techniques; B7510J Optical and laser radiation (biomedical imaging/measurement)
Event End Date:27 January 2010
Deposited On:15 Dec 2010 13:58
Last Modified:05 Apr 2016 14:28
Publisher:Spie - The International Society For Optical Engineering
Series Name:Progress in Biomedical Optics and Imaging
Additional Information:Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XIV, 25-27 January 2010, San Francisco, CA, USA Type: Conference Paper
Publisher DOI:10.1117/12.841159
Official URL:http://spie.org/x648.html?product_id=841159
Other Identification Number:INSPEC:11219547

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