Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive

Redwine, L S; Wirtz, P H; Hong, S; Bosch, J; Ziegler, M G; Greenberg, B; Mills, P J (2010). Depression as a potential modulator of beta-adrenergic -associated leukocyte mobilization in heart failure patients. Journal of the American College of Cardiology, 56(21):1720-1727.

Full text not available from this repository.

View at publisher

Abstract

OBJECTIVES: the aim of this study was to determine whether depressive symptoms are related to alterations in the sensitivity of peripheral blood mononuclear cells to β-adrenergic agonists in patients with heart failure (HF) by measuring in vitro chemotaxis (CTX) to isoproterenol at rest and after acute exercise in patients with HF and controls.

BACKGROUND: clinical outcomes are worse for patients with HF presenting with symptoms of depression. Sympathetically modulated immune dysregulation associated with depression may be one mechanism leading to worse prognosis.

METHODS: seventy-seven patients with HF and 44 controls (mean age 56.4 ± 1.3 years) completed the Beck Depression Inventory and a 15-min mild-graded exercise task on a stationary bicycle. Exercise intensity was kept relative to fitness levels for all participants by gradually increasing resistance to reach a Borg scale subjective rating of 12 to 13, "somewhat hard." Plasma norepinephrine and epinephrine levels were measured before and after exercise. Chemotaxis to isoproterenol was determined by measuring in vitro peripheral blood mononuclear cell migration through a modified Boyden chamber.

RESULTS: In patients with HF, depressive symptom severity was associated with greater CTX after exercise (p = 0.001). Higher resting norepinephrine in patients with HF was also associated with increased CTX to exercise (p = 0.03).

CONCLUSIONS: patients with HF with higher depressive symptoms and norepinephrine exhibited increased peripheral blood mononuclear cell CTX to isoproterenol to mild exercise, suggesting greater β-adrenergic sensitivity. Increased immune migration in patients with HF who have elevated depressive symptoms could be associated with cardiac remodeling and HF disease progression.

Citations

5 citations in Web of Science®
7 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

0 downloads since deposited on 20 Dec 2010
0 downloads since 12 months

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:06 Faculty of Arts > Institute of Psychology
DDC:150 Psychology
Language:English
Date:2010
Deposited On:20 Dec 2010 09:08
Last Modified:28 Nov 2013 00:06
Publisher:Elsevier
ISSN:0735-1097
Publisher DOI:10.1016/j.jacc.2010.04.064
PubMed ID:21070923

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page