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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-4047

Fürst, A; Meier, D; Michel, S; Schmidlin, A; Held , L; Laib, A (2008). Effect of age on bone mineral density and micro architecture in the radius and tibia of horses: An Xtreme computed tomographic study. BMC Veterinary Research, 4(3):1-12.

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Abstract

Background: The effect of age on the bone mineral density and microarchitecture of the equine radius and tibia was investigated. Fifty-six bones from 15 horses aged four to 21 years were used. There were nine geldings and six mares, and none of the horses had any disease influencing bone properties. Xtreme computed tomography was used to evaluate a 9-mm segment of the diaphysis and metaphysis of each bone. The following variables were determined: length of the bone, circumference and diameter in the frontal and sagittal planes in the middle of the bone.

Diaphysis: total volume, bone volume, bone volume ratio, slice area, bone area, marrow area, cortical and marrow thickness, bone mineral density, polar moment of inertia of the cortex.

Metaphysis: total area, bone area, cortical bone area, cortical thickness, bone mineral density, bone mineral density in the cortex, bone mineral density in the trabecular region, trabecular number, trabecular thickness, trabecular separation, polar moment of inertia of the metaphysis, polar moment of inertia of the cortex of the metaphysis.

Results:
Bone density and microarchitecture were not affected by breed or gender. However, the microarchitecture varied with the age of the horse; the number of trabeculae decreased significantly and the distance between trabeculae increased significantly with increasing age. There were no significant differences between bones of the left and right limbs or between the radius and tibia.

Conclusion:
The variables investigated did not differ between geldings and mares. However, there were age-related changes in the microstructure of the bones. Further experimental studies are necessary to determine whether these changes reduce bone strength. Age-related changes in the bones were seen and may explain the higher incidence of fractures and fissures in older horses.

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Social and Preventive Medicine
05 Vetsuisse Faculty > Veterinary Clinic > Equine Department > Equine Clinic
DDC:570 Life sciences; biology
610 Medicine & health
630 Agriculture
Language:English
Date:2008
Deposited On:14 Oct 2008 11:56
Last Modified:27 Nov 2013 23:27
Publisher:BioMed Central
ISSN:1746-6148
Additional Information:Free full text article
Publisher DOI:10.1186/1746-6148-4-3
Official URL:http://www.biomedcentral.com/content/pdf/1746-6148-4-3.pdf
PubMed ID:18221526
Citations:Web of Science®. Times Cited: 6
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Scopus®. Citation Count: 12

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