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Profound depletion of HIV-1 transcription in patients initiating antiretroviral therapy during acute infection


Schmid, A; Gianella, S; von Wyl, V; Metzner, K J; Scherrer, A U; Niederöst, B; Althaus, C F; Rieder, P; Grube, C; Joos, B; Weber, R; Fischer, M; Günthard, H F (2010). Profound depletion of HIV-1 transcription in patients initiating antiretroviral therapy during acute infection. PLoS ONE, 5(10):e13310.

Abstract

Early intervention resulted in profound depletion of PBMC expressing HIV-1 RNA. This is contrary to chronically infected patients who predominantly showed continuous UsRNA expression on cART. Thus, antiretroviral treatment initiated during the acute phase of infection prevented establishment or expansion of long-lived transcriptionally active viral cellular reservoirs in peripheral blood.

Early intervention resulted in profound depletion of PBMC expressing HIV-1 RNA. This is contrary to chronically infected patients who predominantly showed continuous UsRNA expression on cART. Thus, antiretroviral treatment initiated during the acute phase of infection prevented establishment or expansion of long-lived transcriptionally active viral cellular reservoirs in peripheral blood.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Infectious Diseases
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2010
Deposited On:11 Jan 2011 19:08
Last Modified:05 Apr 2016 14:29
Publisher:Public Library of Science (PLoS)
ISSN:1932-6203
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1371/journal.pone.0013310
PubMed ID:20967271
Permanent URL: https://doi.org/10.5167/uzh-40538

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