Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-40538
Schmid, A; Gianella, S; von Wyl, V; Metzner, K J; Scherrer, A U; Niederöst, B; Althaus, C F; Rieder, P; Grube, C; Joos, B; Weber, R; Fischer, M; Günthard, H F (2010). Profound depletion of HIV-1 transcription in patients initiating antiretroviral therapy during acute infection. PLoS ONE, 5(10):e13310.
Early intervention resulted in profound depletion of PBMC expressing HIV-1 RNA. This is contrary to chronically infected patients who predominantly showed continuous UsRNA expression on cART. Thus, antiretroviral treatment initiated during the acute phase of infection prevented establishment or expansion of long-lived transcriptionally active viral cellular reservoirs in peripheral blood.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Clinic for Infectious Diseases|
|DDC:||610 Medicine & health|
|Deposited On:||11 Jan 2011 20:08|
|Last Modified:||27 Nov 2013 20:52|
|Publisher:||Public Library of Science|
|Free access at:||Publisher DOI. An embargo period may apply.|
|Citations:||Web of Science®. Times Cited: 23|
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