UZH-Logo

Maintenance Infos

Podoplanin expression correlates with sentinel lymph node metastasis in early squamous cell carcinomas of the oral cavity and oropharynx


Huber, G F; Fritzsche, F R; et al (2011). Podoplanin expression correlates with sentinel lymph node metastasis in early squamous cell carcinomas of the oral cavity and oropharynx. International Journal of Cancer, 129(6):1404-1409.

Abstract

In patients with early head and neck squamous-cell carcinoma (HNSCC), occult lymph node metastasis is difficult to predict by clinical or pathological parameters. Such parameters however are necessary to select patients either for elective neck dissection or the sentinel lymph node procedure. The membrane glycoprotein podoplanin is normally expressed in lymphatic endothelial cells. Recently, expression of podoplanin by cancer cells was demonstrated to promote tumor cell motility and tumor lymphangiogenesis in vitro. The value of cancer cell-expressed podoplanin was to be determined as a predictive marker for sentinel lymph node (SLN) metastasis in early HNSCC of the oral cavity and oropharynx. 120 patients with HNSCC of the oral cavity and oropharynx undergoing a SLN biopsy were enrolled in this prospective clinical trial of sentinel lymph node biopsy. Cancer cell-expressed podoplanin was determined by immunohistochemistry using tissue microarrays. Podoplanin expression was quantified by the Intensity Reactivity Score (IRS) and categorized into expression and non-expression. SLN examination revealed occult metastasis in 45 patients (37.5%). Twenty nine of 120 (24.2%) primary HNSCC showed podoplanin expression. Podoplanin expression correlated significantly with sentinel lymph node metastasis (p=0.029) and remained a significant predictor for lymph node status even after controlling for tumor stage (p=0.028). As a predictive marker for SLN metastasis however, podoplanin expression reached a sensitivity of a mere 36% and a specificity of 83%. Podoplanin expression is associated with metastasis to lymph nodes in vivo. Podoplanin immunohistochemistry in early HNSCC of the oral cavity and oropharynx may help to select patients for the SLN procedure and to identify patients with increased risk for presence of occult lymph node metastasis in the neck.

Abstract

In patients with early head and neck squamous-cell carcinoma (HNSCC), occult lymph node metastasis is difficult to predict by clinical or pathological parameters. Such parameters however are necessary to select patients either for elective neck dissection or the sentinel lymph node procedure. The membrane glycoprotein podoplanin is normally expressed in lymphatic endothelial cells. Recently, expression of podoplanin by cancer cells was demonstrated to promote tumor cell motility and tumor lymphangiogenesis in vitro. The value of cancer cell-expressed podoplanin was to be determined as a predictive marker for sentinel lymph node (SLN) metastasis in early HNSCC of the oral cavity and oropharynx. 120 patients with HNSCC of the oral cavity and oropharynx undergoing a SLN biopsy were enrolled in this prospective clinical trial of sentinel lymph node biopsy. Cancer cell-expressed podoplanin was determined by immunohistochemistry using tissue microarrays. Podoplanin expression was quantified by the Intensity Reactivity Score (IRS) and categorized into expression and non-expression. SLN examination revealed occult metastasis in 45 patients (37.5%). Twenty nine of 120 (24.2%) primary HNSCC showed podoplanin expression. Podoplanin expression correlated significantly with sentinel lymph node metastasis (p=0.029) and remained a significant predictor for lymph node status even after controlling for tumor stage (p=0.028). As a predictive marker for SLN metastasis however, podoplanin expression reached a sensitivity of a mere 36% and a specificity of 83%. Podoplanin expression is associated with metastasis to lymph nodes in vivo. Podoplanin immunohistochemistry in early HNSCC of the oral cavity and oropharynx may help to select patients for the SLN procedure and to identify patients with increased risk for presence of occult lymph node metastasis in the neck.

Citations

22 citations in Web of Science®
25 citations in Scopus®
Google Scholar™

Altmetrics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Otorhinolaryngology
04 Faculty of Medicine > University Hospital Zurich > Institute of Surgical Pathology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2011
Deposited On:22 Dec 2010 08:18
Last Modified:05 Apr 2016 14:30
Publisher:Wiley-Blackwell
ISSN:0020-7136
Publisher DOI:https://doi.org/10.1002/ijc.25795
PubMed ID:21105028

Download

Full text not available from this repository.
View at publisher

TrendTerms

TrendTerms displays relevant terms of the abstract of this publication and related documents on a map. The terms and their relations were extracted from ZORA using word statistics. Their timelines are taken from ZORA as well. The bubble size of a term is proportional to the number of documents where the term occurs. Red, orange, yellow and green colors are used for terms that occur in the current document; red indicates high interlinkedness of a term with other terms, orange, yellow and green decreasing interlinkedness. Blue is used for terms that have a relation with the terms in this document, but occur in other documents.
You can navigate and zoom the map. Mouse-hovering a term displays its timeline, clicking it yields the associated documents.

Author Collaborations