Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-40833

Comabella, M; Montalban, X; Kakalacheva, K; Osman, D; Nimmerjahn, F; Tintoré, M; Lünemann, J D (2010). B cell expression of the inhibitory Fc gamma receptor is unchanged in early MS. Journal of Neuroimmunology, 223(1-2):135-137.

[img] PDF - Registered users only
1MB

View at publisher

Abstract

Expression of the inhibitory Fcgamma receptor IIB (FcgammaRIIB) has emerged as a late checkpoint during peripheral B cell development which prevents autoreactive memory B lymphocytes from becoming long-lived plasma cells. Decreased expression of FcgammaRIIB or non-functional FcgammaRIIB variants are associated with the development of autoimmune tissue inflammation. We determined the expression profile of FcgammaRIIB in peripheral blood cells in treatment-naïve patients with early MS. Twenty-five patients with clinically isolated syndrome (CIS) who converted to clinically definite MS (CDMS) and 25 demographically matched healthy donors were included in the study. Frequencies of peripheral blood monocytes and B cell subsets as well as FcgammaRIIB expression profile was determined by flow cytometry. FcgammaRIIB expression levels were higher in B cells compared to monocytes (p<0.0001) and higher in memory B cells compared to their naïve counterparts (p<0.0001). However, FcgammaRIIB expression in naïve and memory B cells as well as monocytes was unchanged in patients with early MS at onset of symptoms as well as after conversion to CDMS compared to controls. No significant correlations were found between FcgammaRIIB expression levels and brain MRI-derived metrics or EDSS progression during follow-up. These data indicate that FcgammaRIIB expression, a critical late B cell differentiation checkpoint preventing the occurrence of autoreactive long-lived plasma cells, is not impaired in treatment-naïve patients with MS, at least in the early phases of the disease.

Citations

2 citations in Web of Science®
3 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

2 downloads since deposited on 16 Jan 2011
0 downloads since 12 months

Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Psychiatry and Psychotherapy
DDC:610 Medicine & health
Language:English
Date:2010
Deposited On:16 Jan 2011 18:59
Last Modified:28 Nov 2013 01:57
Publisher:Elsevier
ISSN:0165-5728
Publisher DOI:10.1016/j.jneuroim.2010.03.015
PubMed ID:20399509

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page