Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-40835
Comabella, M; Montalban, X; Horga, A; Messmer, B; Kakalacheva, K; Strowig, T; Caballero, E; Münz, C; Lünemann, J D (2010). Antiviral immune response in patients with multiple sclerosis and healthy siblings. Multiple Sclerosis, 16(3):355-358.
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The objective of this study was to determine the immune responses to candidate viral triggers of multiple sclerosis in patients and healthy siblings raised in the same family household. Virus antigen-specific IgG responses to Epstein-Barr virus-derived gene products as well as to human herpersvirus-6, human cytomegalovirus, and measles virus were evaluated in 25 multiple sclerosis patients and compared with 49 healthy full-siblings. IgG responses to the latent Epstein-Barr virus-encoded nuclear antigen-1 (EBNA1) were selectively increased in individuals with multiple sclerosis compared with their unaffected siblings. We conclude that elevated IgG responses towards EBNA1 are associated with the development of multiple sclerosis.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Clinic for Psychiatry and Psychotherapy|
04 Faculty of Medicine > University Hospital Zurich > Institute of Experimental Immunology
|DDC:||570 Life sciences; biology|
610 Medicine & health
|Deposited On:||16 Jan 2011 19:52|
|Last Modified:||28 Nov 2013 00:33|
|Citations:||Web of Science®. Times cited: 5|
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