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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-40838

Klein, L; Münz, C; Lünemann, J D (2010). Autophagy-mediated antigen processing in CD4(+) T cell tolerance and immunity. FEBS Letters, 584(7):1405-1410.

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Abstract

Macroautophagy, a homeostatic process that shuttles cytoplasmic constituents into endosomal and lysosomal compartments, has recently been shown to deliver antigens for presentation on major histocompatibility complex (MHC) class II. Autophagy-mediated antigen processing in thymic epithelial cells has been suggested to be involved in the generation of a self-MHC restricted and self-tolerant CD4(+) T cell repertoire. Furthermore, there is accumulating evidence that the up-regulation of autophagy by pattern-recognition receptor signaling represents an innate defense mechanism against intracellular pathogens. Thus, through linking pathogen breakdown with the presentation of pathogen-derived autophagy substrates on MHC class II, autophagy serves a dual function at the interface of the innate and the adaptive immune response.

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Psychiatry and Psychotherapy
04 Faculty of Medicine > University Hospital Zurich > Institute of Experimental Immunology
DDC:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2010
Deposited On:16 Jan 2011 21:11
Last Modified:27 Nov 2013 23:55
Publisher:Elsevier
ISSN:0014-5793
Publisher DOI:10.1016/j.febslet.2010.01.008
PubMed ID:20074571
Citations:Web of Science®. Times Cited: 5
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