Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-40838
Klein, L; Münz, C; Lünemann, J D (2010). Autophagy-mediated antigen processing in CD4(+) T cell tolerance and immunity. FEBS Letters, 584(7):1405-1410.
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Macroautophagy, a homeostatic process that shuttles cytoplasmic constituents into endosomal and lysosomal compartments, has recently been shown to deliver antigens for presentation on major histocompatibility complex (MHC) class II. Autophagy-mediated antigen processing in thymic epithelial cells has been suggested to be involved in the generation of a self-MHC restricted and self-tolerant CD4(+) T cell repertoire. Furthermore, there is accumulating evidence that the up-regulation of autophagy by pattern-recognition receptor signaling represents an innate defense mechanism against intracellular pathogens. Thus, through linking pathogen breakdown with the presentation of pathogen-derived autophagy substrates on MHC class II, autophagy serves a dual function at the interface of the innate and the adaptive immune response.
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|Item Type:||Journal Article, refereed, further contribution|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Clinic for Psychiatry and Psychotherapy
04 Faculty of Medicine > Institute of Experimental Immunology
|DDC:||570 Life sciences; biology
610 Medicine & health
|Deposited On:||16 Jan 2011 20:11|
|Last Modified:||27 Nov 2013 22:55|
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