Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-40840

Ganter, M T; Pittet, J F (2010). New insights into acute coagulopathy in trauma patients. Best Practice & Research: Clinical Anaesthesiology, 24(1):15-25.

[img]
Preview
Accepted Version
PDF
286kB

View at publisher

Abstract

Abnormal coagulation parameters can be found in 25% of trauma patients with major injuries. Furthermore, trauma patients presenting with coagulopathy on admission have worse clinical outcome. Tissue trauma and systemic hypoperfusion appear to be the primary factors responsible for the development of acute traumatic coagulopathy immediately after injury. As a result of overt activation of the protein C pathway, the acute traumatic coagulopathy is characterised by coagulopathy in conjunction with hyperfibrinolysis. This coagulopathy can then be exacerbated by subsequent physiologic and physical derangements such as consumption of coagulation factors, haemodilution, hypothermia, acidemia and inflammation, all factors being associated with ongoing haemorrhage and inadequate resuscitation or transfusion therapies. Knowledge of the different mechanisms involved in the pathogenesis of acute traumatic coagulopathy is essential for successful management of bleeding trauma patients. Therefore, early evidence suggests that treatment directed at aggressive and targeted haemostatic resuscitation can lead to reductions in mortality of severely injured patients.

Citations

Altmetrics

Downloads

124 downloads since deposited on 17 Jan 2011
14 downloads since 12 months

Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Anesthesiology
DDC:610 Medicine & health
Language:English
Date:2010
Deposited On:17 Jan 2011 13:36
Last Modified:23 Nov 2012 23:43
Publisher:Elsevier
ISSN:1753-3740
Publisher DOI:10.1016/j.bpa.2009.09.010
PubMed ID:20402167

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page