Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-4124
von Poser-Klein, C; Flechsig, E; Hoffmann, T; Schwarz, P; Harms, H; Bujdoso, R; Aguzzi, A; Klein, M A (2008). Alteration of B-cell subsets enhances neuroinvasion in mouse scrapie infection. Journal of Virology, 82(7):3791-3795.
View at publisher
Acquired forms of prion diseases or transmissible spongiform encephalopathies are believed to occur following peripheral exposure. Prions initially accumulate in the lymphoid system before spreading to the nervous system, but the underlying mechanisms for prion transfer between the two systems are still elusive. Here we show that ablation of the B-cell-specific transmembrane protein CD19, a coreceptor of the complement system, results in an acceleration of prion neuroinvasion. This appears to be due to an alteration of the follicular dendritic cell (FDC) network within the lymphoid tissue, thereby reducing the distance between FDCs and adjacent nerve fibers that mediate prion neuroinvasion.
32 downloads since deposited on 14 Nov 2008
12 downloads since 12 months
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > University Hospital Zurich > Institute of Neuropathology|
|DDC:||570 Life sciences; biology
610 Medicine & health
|Deposited On:||14 Nov 2008 17:13|
|Last Modified:||27 Nov 2013 17:17|
|Publisher:||American Society for Microbiology|
|Additional Information:||Copyright: American Society for Microbiology|
Users (please log in): suggest update or correction for this item
Repository Staff Only: item control page