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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-41384

Wilkoff, B L; Bello, D; Taborsky, M; Vymazal, J; Kanal, E; Heuer, H; Hecking, K; Johnson, W B; Young, W; Ramza, B; Akhtar, N; Kuepper, B; Hunold, P; Luechinger, R; Puererfellner, H; Duru, F; Gotte, M J W; Sutton, R; Sommer, T (2011). Magnetic resonance imaging in patients with a pacemaker system designed for the magnetic resonance environment. Heart Rhythm, 8(1):65-73.

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Abstract

Background

Magnetic resonance imaging (MRI) of pacemaker patients is contraindicated due to documented potential risks to the patient from hazardous interactions between the MRI and pacemaker system.
Objective

The purpose of this prospective, randomized, controlled, worldwide clinical trial was to evaluate the safety and effectiveness of a pacemaker system designed for safe use in MRI for any bradycardia indicated patient.
Methods

Patients (n = 464) were randomized to undergo an MRI scan between 9 and 12 weeks postimplant (MRI group, n = 258) or not to undergo MRI (control group, n = 206) after successful implantation of the specially designed dual-chamber pacemaker and leads. Patients were monitored for arrhythmias, symptoms, and pacemaker system function during 14 nonclinically indicated relevant brain and lumbar MRI sequences. Sequences were performed at 1.5 T and included scans with high radiofrequency power deposition and/or high gradient dB/dt exposure. Clinical evaluation of the pacemaker system function occurred immediately before and after MRI, 1 week and 1 month post-MRI, and at corresponding times for the control group. Primary endpoints for safety analyzed the MRI procedure complication-free rate and for effectiveness compared capture and sensing performance between MRI and control groups.
Results

No MRI-related complications occurred during or after MRI, including sustained ventricular arrhythmias, pacemaker inhibition or output failures, electrical resets, or other pacemaker malfunctions. Pacing capture threshold and sensed electrogram amplitude changes were minimal and similar between study groups.
Conclusion

This trial documented the ability of this pacemaker system to be exposed in a controlled fashion to MRI in a 1.5 T scanner without adverse impact on patient outcomes or pacemaker system function.

Citations

60 citations in Web of Science®
83 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Cardiology
04 Faculty of Medicine > Institute of Biomedical Engineering
DDC:170 Ethics
610 Medicine & health
Language:English
Date:1 January 2011
Deposited On:05 Jan 2011 08:49
Last Modified:28 Nov 2013 02:08
Publisher:Elsevier
ISSN:1547-5271
Publisher DOI:10.1016/j.hrthm.2010.10.002
PubMed ID:20933098

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