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Metabolic modulator perhexiline corrects energy deficiency and improves exercise capacity in symptomatic hypertrophic cardiomyopathy


Abozguia, K; Elliott, P; McKenna, W; Phan, T T; Nallur Shivu, G; Ahmed, I; Maher, A R; Kaur, K; Taylor, J; Henning, A; Ashrafian, H; Watkins, H; Frenneaux, M (2010). Metabolic modulator perhexiline corrects energy deficiency and improves exercise capacity in symptomatic hypertrophic cardiomyopathy. Circulation, 122(16):1562-1569.

Abstract

In symptomatic hypertrophic cardiomyopathy, perhexiline, a modulator of substrate metabolism, ameliorates cardiac energetic impairment, corrects diastolic dysfunction, and increases exercise capacity. This study supports the hypothesis that energy deficiency contributes to the pathophysiology and provides a rationale for further consideration of metabolic therapies in hypertrophic cardiomyopathy.

In symptomatic hypertrophic cardiomyopathy, perhexiline, a modulator of substrate metabolism, ameliorates cardiac energetic impairment, corrects diastolic dysfunction, and increases exercise capacity. This study supports the hypothesis that energy deficiency contributes to the pathophysiology and provides a rationale for further consideration of metabolic therapies in hypertrophic cardiomyopathy.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Biomedical Engineering
Dewey Decimal Classification:170 Ethics
610 Medicine & health
Language:English
Date:4 October 2010
Deposited On:05 Jan 2011 08:40
Last Modified:05 Apr 2016 14:32
Publisher:Lippincott Wiliams & Wilkins
ISSN:0009-7322
Publisher DOI:10.1161/CIRCULATIONAHA.109.934059
PubMed ID:20921440
Permanent URL: http://doi.org/10.5167/uzh-41386

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