Quick Search:

uzh logo
Browse by:

Zurich Open Repository and Archive

Maintenance: Tuesday, 5.7.2016, 07:00-08:00

Maintenance work on ZORA and JDB on Tuesday, 5th July, 07h00-08h00. During this time there will be a brief unavailability for about 1 hour. Please be patient.

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-41386

Abozguia, K; Elliott, P; McKenna, W; Phan, T T; Nallur Shivu, G; Ahmed, I; Maher, A R; Kaur, K; Taylor, J; Henning, A; Ashrafian, H; Watkins, H; Frenneaux, M (2010). Metabolic modulator perhexiline corrects energy deficiency and improves exercise capacity in symptomatic hypertrophic cardiomyopathy. Circulation, 122(16):1562-1569.

[img] PDF - Registered users only
View at publisher


In symptomatic hypertrophic cardiomyopathy, perhexiline, a modulator of substrate metabolism, ameliorates cardiac energetic impairment, corrects diastolic dysfunction, and increases exercise capacity. This study supports the hypothesis that energy deficiency contributes to the pathophysiology and provides a rationale for further consideration of metabolic therapies in hypertrophic cardiomyopathy.


86 citations in Web of Science®
108 citations in Scopus®
Google Scholar™



0 downloads since deposited on 05 Jan 2011
0 downloads since 12 months

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Biomedical Engineering
Dewey Decimal Classification:170 Ethics
610 Medicine & health
Date:4 October 2010
Deposited On:05 Jan 2011 08:40
Last Modified:05 Apr 2016 14:32
Publisher:Lippincott Wiliams & Wilkins
Publisher DOI:10.1161/CIRCULATIONAHA.109.934059
PubMed ID:20921440

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page