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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-41556

Jenni, D; Karpova, M B; Seifert, Burkhardt; Golling, P; Cozzio, A; Kempf, W; French, L E; Dummer, R (2011). Primary cutaneous lymphoma: Two-decade comparison in a population of 263 cases from a Swiss tertiary referral centre. British Journal of Dermatology, 164(5):1071-1077.

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Background:  Epidemiologic data on primary cutaneous lymphomas (PCL) are rare and up to now have not been investigated in Switzerland. Objective:  To analyze variations in demographics, pattern of subtypes and staging during the two ten-year intervals: 1990-1999 and 2000-2009. Methods:  Descriptive study of 263 PCL patients based on a retrospective review and reassessment according to the WHO-EORTC classification. Results:  Change was observed in the pattern of cutaneous T-cell lymphoma subtypes: Sézary Syndrome frequency decreased (17-7%); CD30+ lymphoproliferative disorders frequency increased (7-18%; common p=0.04). Staging of PCL showed a higher number of early stage Mycosis fungoides cases (p=0.01). In relation to the international data, Zurich showed a higher number of Sézary Syndrome (11% vs. 3%) and Marginal Cell Lymphoma (14% vs. 5-7%) patients. Additionally, comparison of the survival data showed prolonged median overall survival of Zurich Sézary Syndrome patients in the second ten-year interval (6.5 vs. 2-4 years). Conclusion:  The increasing frequency of marginal cell lymphoma and CD30+ lymphoproliferative disorders might depend on an increased awareness of these diseases in the medical community driven by progress in the classification and staging of these disease entities.


15 citations in Web of Science®
20 citations in Scopus®
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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Epidemiology, Biostatistics and Prevention Institute (EBPI)
04 Faculty of Medicine > University Hospital Zurich > Dermatology Clinic
Dewey Decimal Classification:610 Medicine & health
Deposited On:09 Jan 2011 17:30
Last Modified:05 Apr 2016 14:32
Publisher DOI:10.1111/j.1365-2133.2010.10143.x
PubMed ID:21083546

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