Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-41556
Jenni, D; Karpova, M B; Seifert, B; Golling, P; Cozzio, A; Kempf, W; French, L E; Dummer, R (2011). Primary cutaneous lymphoma: Two-decade comparison in a population of 263 cases from a Swiss tertiary referral centre. British Journal of Dermatology, 164(5):1071-1077.
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Background: Epidemiologic data on primary cutaneous lymphomas (PCL) are rare and up to now have not been investigated in Switzerland. Objective: To analyze variations in demographics, pattern of subtypes and staging during the two ten-year intervals: 1990-1999 and 2000-2009. Methods: Descriptive study of 263 PCL patients based on a retrospective review and reassessment according to the WHO-EORTC classification. Results: Change was observed in the pattern of cutaneous T-cell lymphoma subtypes: Sézary Syndrome frequency decreased (17-7%); CD30+ lymphoproliferative disorders frequency increased (7-18%; common p=0.04). Staging of PCL showed a higher number of early stage Mycosis fungoides cases (p=0.01). In relation to the international data, Zurich showed a higher number of Sézary Syndrome (11% vs. 3%) and Marginal Cell Lymphoma (14% vs. 5-7%) patients. Additionally, comparison of the survival data showed prolonged median overall survival of Zurich Sézary Syndrome patients in the second ten-year interval (6.5 vs. 2-4 years). Conclusion: The increasing frequency of marginal cell lymphoma and CD30+ lymphoproliferative disorders might depend on an increased awareness of these diseases in the medical community driven by progress in the classification and staging of these disease entities.
|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||04 Faculty of Medicine > Institute of Social and Preventive Medicine|
04 Faculty of Medicine > University Hospital Zurich > Dermatology Clinic
|DDC:||610 Medicine & health|
|Deposited On:||09 Jan 2011 18:30|
|Last Modified:||23 Nov 2012 16:46|
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