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Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-41610

Pfefferle, P I; Büchele, G; Blümer, N; Roponen, M; Ege, M J; Krauss-Etschmann, S; Genuneit, J; Hyvärinen, A; Hirvonen, M R; Lauener, R; Pekkanen, J; Riedler, J; Dalphin, J C; Brunekeef, B; Braun-Fahrländer, C; von Mutius, E; Renz, H (2010). Cord blood cytokines are modulated by maternal farming activities and consumption of farm dairy products during pregnancy: the PASTURE Study. Journal of Allergy and Clinical Immunology, 125(1):108-115.e1.

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BACKGROUND: Traditional farming represents a unique model situation to investigate the relationship of early-life farm-related exposure and allergy protection.

OBJECTIVES: To investigate associations between maternal farm exposures and cytokine production in cord blood (CB) mononuclear cells in a prospective multinational birth cohort of 299 farm and 326 nonfarm children and their families.

METHODS: Supernatants from phorbol 12-myristate 13-acetate/ionomycin-stimulated CB mononuclear cells were assessed for the production of IFN-gamma, TNF-alpha, IL-5, IL-10, and IL-12.

RESULTS: Significantly higher levels of IFN-gamma and TNF-alpha in farm compared with nonfarm children were found, whereas IL-5, IL-10, and IL-12 levels did not differ between study groups. Maternal contact with different farm animal species and barns and consumption of farm-produced butter during pregnancy enhanced the production of proinflammatory CB cytokines, whereas maternal consumption of farm-produced yogurt resulted in significant lower levels of IFN-gamma and TNF-alpha in umbilical blood.

CONCLUSION: Maternal exposure to farming activities and farm dairy products during pregnancy modulated cytokine production patterns of offspring at birth.
Copyright 2010 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.


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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Children's Hospital Zurich > Medical Clinic
Dewey Decimal Classification:610 Medicine & health
Deposited On:22 Jan 2011 15:57
Last Modified:05 Apr 2016 14:33
Publisher DOI:10.1016/j.jaci.2009.09.019
PubMed ID:19969338

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