Quick Search:

uzh logo
Browse by:
bullet
bullet
bullet
bullet

Zurich Open Repository and Archive

Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-41662

Scharf, W; Schauer, S; Freyburger, F; Petrovec, M; Schaarschmidt-Kiener, D; Liebisch, G; Runge, M; Ganter, M T; Kehl, A; Dumler, J S; García-Pérez, A L; Jensen, J; Fingerle, V; Meli, M L; Ensser, A; Stuen, S; von Loewenich, F D (2011). Distinct host species correlate with Anaplasma phagocytophilum ankA gene clusters. Journal of Clinical Microbiology, 49(3):790-796.

[img]
Preview
Accepted Version
PDF
1MB

View at publisher

Abstract

Anaplasma phagocytophilum is a Gram-negative, tick-transmitted, obligate intracellular bacterium that elicits acute febrile diseases in humans and domestic animals. In contrast to the United States, human granulocytic anaplasmosis seems to be a rare disease in Europe despite the initial recognition of A. phagocytophilum as the causative agent of tick-borne fever in European sheep and cattle. Considerable strain variation has been suggested to occur within this species, because isolates from humans and animals differed in their pathogenicity for heterologous hosts. In order to explain host preference and epidemiological diversity, molecular characterization of A. phagocytophilum strains has been undertaken. Most often the 16S rRNA gene was used, but it might be not informative enough to delineate distinct genotypes of A. phagocytophilum. Previously, we have shown that A. phagocytophilum strains infecting Ixodes ricinus ticks are highly diverse in their ankA genes. Therefore we sequenced the 16S rRNA and ankA genes of 194 A. phagocytophilum strains from humans and several animal species. Whereas the phylogenetic analysis using 16S rRNA gene sequences was not meaningful, we showed that distinct host species correlate with A. phagocytophilum ankA gene clusters.

Citations

38 citations in Web of Science®
36 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

133 downloads since deposited on 17 Jan 2011
69 downloads since 12 months

Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Veterinary Clinic > Department of Farm Animals
DDC:570 Life sciences; biology
630 Agriculture
Language:English
Date:2011
Deposited On:17 Jan 2011 15:35
Last Modified:30 Oct 2014 16:03
Publisher:American Society for Microbiology
ISSN:0095-1137
Publisher DOI:10.1128/JCM.02051-10
PubMed ID:21177886

Users (please log in): suggest update or correction for this item

Repository Staff Only: item control page