Permanent URL to this publication: http://dx.doi.org/10.5167/uzh-41662
Scharf, W; Schauer, S; Freyburger, F; Petrovec, M; Schaarschmidt-Kiener, D; Liebisch, G; Runge, M; Ganter, M T; Kehl, A; Dumler, J S; García-Pérez, A L; Jensen, J; Fingerle, V; Meli, M L; Ensser, A; Stuen, S; von Loewenich, F D (2011). Distinct host species correlate with Anaplasma phagocytophilum ankA gene clusters. Journal of Clinical Microbiology, 49(3):790-796.
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Anaplasma phagocytophilum is a Gram-negative, tick-transmitted, obligate intracellular bacterium that elicits acute febrile diseases in humans and domestic animals. In contrast to the United States, human granulocytic anaplasmosis seems to be a rare disease in Europe despite the initial recognition of A. phagocytophilum as the causative agent of tick-borne fever in European sheep and cattle. Considerable strain variation has been suggested to occur within this species, because isolates from humans and animals differed in their pathogenicity for heterologous hosts. In order to explain host preference and epidemiological diversity, molecular characterization of A. phagocytophilum strains has been undertaken. Most often the 16S rRNA gene was used, but it might be not informative enough to delineate distinct genotypes of A. phagocytophilum. Previously, we have shown that A. phagocytophilum strains infecting Ixodes ricinus ticks are highly diverse in their ankA genes. Therefore we sequenced the 16S rRNA and ankA genes of 194 A. phagocytophilum strains from humans and several animal species. Whereas the phylogenetic analysis using 16S rRNA gene sequences was not meaningful, we showed that distinct host species correlate with A. phagocytophilum ankA gene clusters.
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|Item Type:||Journal Article, refereed, original work|
|Communities & Collections:||05 Vetsuisse Faculty > Veterinary Clinic > Department of Farm Animals|
|Dewey Decimal Classification:||570 Life sciences; biology
|Deposited On:||17 Jan 2011 15:35|
|Last Modified:||30 Oct 2014 16:03|
|Publisher:||American Society for Microbiology|
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